(S)-2-(((R)-tetrahydrofuran-3-yl)methoxy)propanoic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧唑烯
• 英文名称: (S)-2-(((R)-tetrahydrofuran-3-yl)methoxy)propanoic acid
• 英文别名: (2S)-2-[[(3R)-oxolan-3-yl]methoxy]propanoic acid
• 化学式: C₈H₁₄O₄
• 分子量: 174.197
• InChiKey: FFMWIIMVNJMLSN-NKWVEPMBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Pyrazolo pyrimidine derivatives and their use as MALT1 inhbitors
  申请人：NOVARTIS AG

  公开号：US10442808B2

  公开（公告）日：2019-10-15

  The present invention describes new pyrazolo-pyrimidine derivatives according to Formula (I) which are generally interacting with MALT1 proteolytic and/or autoproteolytic activity, and in particular which may inhibit said activity. The present invention further describes the synthesis of said new pyrazolo-pyrimidine derivatives, their use as a medicament, especially by interacting with MALT1 proteolytic and/or autoproteolytic activity.

  本发明描述了符合式（I）的新吡唑嘧啶衍生物 的新吡唑嘧啶衍生物，它们通常与 MALT1 蛋白水解和/或自体蛋白水解活性相互作用，特别是可以抑制上述活性。本发明进一步描述了上述新吡唑嘧啶衍生物的合成及其作为药物的用途，特别是通过与 MALT1 蛋白溶解和/或自体蛋白溶解活性相互作用。
• NOVEL PYRAZOLO PYRIMIDINE DERIVATIVES AND THEIR USE AS MALT1 INHIBITORS
  申请人：Novartis AG

  公开号：EP3149001B1

  公开（公告）日：2019-04-24
• NOVEL PYRAZOLO PYRIMIDINE DERIVATIVES AND THEIR USE AS MALT1 INHBITORS
  申请人：Soldermann Carole Pissot

  公开号：US20170121335A1

  公开（公告）日：2017-05-04

  The present invention describes new pyrazolo-pyrimidine derivatives which are generally interacting with MALT1 proteolytic and/or autoproteolytic activity, and in particular which may inhibit said activity. The present invention further describes the synthesis of said new pyrazolo-pyrimidine derivatives, their use as a medicament, especially by interacting with MALT1 proteolytic and/or autoproteolytic activity.
• US9815842B2
  申请人：——

  公开号：US9815842B2

  公开（公告）日：2017-11-14