N-(6-溴吡啶-2-基)烟酰胺 | 1140964-62-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: N-(6-溴吡啶-2-基)烟酰胺
• 英文名称: N-(6-bromopyridin-2-yl)nicotinamide
• 英文别名: N-(6-bromopyridin-2-yl)pyridine-3-carboxamide
• CAS: 1140964-62-0
• 化学式: C₁₁H₈BrN₃O
• 分子量: 278.108
• InChiKey: JOOPBJBIYHFXST-UHFFFAOYSA-N

物化性质

• 沸点：
  332.7±32.0 °C(Predicted)
• 密度：
  1.626±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  54.9
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2,6-二溴吡啶 、 烟酰胺 在 二氯双(三邻甲苯膦)合钯(II) 、 caesium carbonate 、 R-(+)-1,1'-联萘-2,2'-双二苯膦 作用下， 反应 72.0h， 以42%的产率得到2-氨基-6-溴吡啶
  参考文献：
  名称：

  Direct synthesis of primary arylamines via C–N cross-coupling of aryl bromides and triflates with amides

  摘要：

  Aryl halides and triflates are coupled with primary amides to give the corresponding arylamines in the presence of a palladium catalyst, a suitable ligand, and a base. The catalyst system performs well for a large number of different substrates at 100-150 degrees C without solvent, and with low catalyst levels (0.12 mol% Pd). Nicotinamide might be useful as a nitrogen source in the Pd-catalyzed amination reaction. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2009.01.033

文献信息

• Direct synthesis of primary arylamines via C–N cross-coupling of aryl bromides and triflates with amides
  作者：M. Romero、Y. Harrak、J. Basset、J.A. Orúe、M.D. Pujol

  DOI：10.1016/j.tet.2009.01.033

  日期：2009.3

  Aryl halides and triflates are coupled with primary amides to give the corresponding arylamines in the presence of a palladium catalyst, a suitable ligand, and a base. The catalyst system performs well for a large number of different substrates at 100-150 degrees C without solvent, and with low catalyst levels (0.12 mol% Pd). Nicotinamide might be useful as a nitrogen source in the Pd-catalyzed amination reaction. (C) 2009 Elsevier Ltd. All rights reserved.