N-(7-氨基-1-氯-2-氧代庚烷-3-基)-4-甲基苯磺酰胺 | 2104-86-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: N-(7-氨基-1-氯-2-氧代庚烷-3-基)-4-甲基苯磺酰胺
• 英文名称: tosyllysine chloromethyl ketone
• 英文别名: TLCK；N-(7-amino-1-chloro-2-oxoheptan-3-yl)-4-methylbenzenesulfonamide
• CAS: 2104-86-1
• 化学式: C₁₄H₂₁ClN₂O₃S
• 分子量: 332.851
• InChiKey: RDFCSSHDJSZMTQ-UHFFFAOYSA-N

物化性质

• 沸点：
  509.8±60.0 °C(Predicted)
• 密度：
  1.242±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  21
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  97.6
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Use of standards for monitoring alterations of peptide and protein samples
  申请人：BioVisioN AG

  公开号：EP1619503A1

  公开（公告）日：2006-01-25

  The present invention is directed to methods of using standards for determining and monitoring alterations and variations of peptide and protein samples. More specifically, the present invention relates to methods of determining and monitoring alterations of the sample quality, in particular after collection, during processing and during storage of the sample.

  本发明涉及使用标准品确定和监测肽和蛋白质样品的变化和变异的方法。更具体地说，本发明涉及确定和监测样品质量变化的方法，特别是在样品采集后、处理过程中和储存期间。
• Improved bone graft
  申请人：Osteotech, Inc.,

  公开号：EP2295088A1

  公开（公告）日：2011-03-16

  The invention provides an osteoinductive composition for implantation at a bone defect site which comprises osteoinductive demineralized bone matrix in a carrier of hydrated polysaccharide, the type and quantity of polysaccharide present in the carrier being sufficient, upon hydration, of importing flowability to the composition and providing an osteoinductive activity of at least 1 as measured by the athymic rat model assay. The polysaccharide may be selected from the group consisting of starch and cellulose.

  本发明提供了一种用于植入骨缺损部位的骨诱导性组合物，该组合物包含在水合多糖载体中的骨诱导性脱矿物质骨基质，载体中存在的多糖的类型和数量在水合后足以为组合物带来流动性，并通过无胸腺大鼠模型试验测定提供至少 1 的骨诱导活性。多糖可选自淀粉和纤维素。
• Methods for cyclic nucleotide determination
  申请人：Promega Corporation

  公开号：EP2400029A2

  公开（公告）日：2011-12-28

  The present invention relates in general to cellular analysis tools and more particularly to methods of determining cyclic nucleotide concentrations in samples.

  本发明总体上涉及细胞分析工具，更具体地说，涉及确定样品中环核苷酸浓度的方法。
• Assay for phosphodiesterases
  申请人：Promega Corporation

  公开号：EP2392667A2

  公开（公告）日：2011-12-07

  The present invention relates in general to cellular analysis tools and more particularly to methods of determining cyclic nucleotide concentrations in samples.

  本发明总体上涉及细胞分析工具，更具体地说，涉及确定样品中环核苷酸浓度的方法。
• Devices for treating disorders of a paranasal sinus
  申请人：Acclarent, Inc.

  公开号：EP2532383A2

  公开（公告）日：2012-12-12

  A catheter device (1000) for treating a disease or disorder of a paranasal sinus having an ostium which opens into said paranasal sinus, said device comprising: a catheter shaft (1002) having a distal end, said catheter shaft being suitable for advancing, distal end first, through the ostium and into the paranasal sinus; a distal balloon (1006) for positioning inside the paranasal sinus adjacent to the ostium; a proximal balloon (1004) for positioning outside the paranasal sinus adjacent to the ostium; and at least one balloon inflation lumen extending through the catheter shaft (1002) for inflation of said distal and proximal balloons (1006,1004), said device further comprising a lumen that is sized to receive a guidewire such that the device may be advanced over a guidewire.

  一种用于治疗副鼻窦疾病或失调的导管装置（1000），该副鼻窦具有开口进入所述副鼻窦的骨膜，所述装置包括：具有远端的导管轴 (1002)，所述导管轴适用于先将远端推进，穿过开口并进入副鼻窦；远端球囊 (1006)，用于定位在邻近开口的副鼻窦内；近端球囊 (1004)，用于定位在邻近开口的副鼻窦外；以及至少一个球囊充气管腔，该管腔延伸穿过导管轴 (1002)，用于对所述远端和近端球囊 (1006,1004) 进行充气，所述装置还包括一个管腔，该管腔的大小可接收导丝，从而使装置可在导丝上方推进。