collismycin B | 158792-25-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: collismycin B
• 英文别名: Collismycin B；(NZ)-N-[(4-methoxy-3-methylsulfanyl-6-pyridin-2-ylpyridin-2-yl)methylidene]hydroxylamine
• CAS: 158792-25-7
• 化学式: C₁₃H₁₃N₃O₂S
• 分子量: 275.331
• InChiKey: NQGMIPUYCWIEAW-NVNXTCNLSA-N

物化性质

• 沸点：
  450.7±45.0 °C(Predicted)
• 密度：
  1.27±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  92.9
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  (2E)-4-甲氧基-3-甲硫基-2-(亚硝基亚甲基)-6-(2-吡啶基)-1H-吡啶 以 邻二氯苯 为溶剂， 生成 collismycin B
  参考文献：
  名称：

  Collismycins A and B, novel non-steroidal inhibitors of denamethasone-glucocorticoid receptor binding.

  摘要：

  DOI：

  10.7164/antibiotics.47.1072

文献信息

• USE OF COLLISMYCIN AND DERIVATIVES THEREOF AS OXIDATIVE STRESS INHIBITORS
  申请人：Martinez Gil Ana

  公开号：US20100048635A2

  公开（公告）日：2010-02-25

  The present invention relates to the use of Collismycin and derivatives thereof as inhibitors of oxidative stress in cells and their use for the preparation of medicaments for the treatment and/or prevention of oxidative stress-induced diseases or conditions, especially neurodegenerative diseases, such as Alzheimer's Disease and Parkinson's Disease.

  本发明涉及使用Collismycin及其衍生物作为细胞内氧化应激的抑制剂，以及它们用于制备治疗和/或预防氧化应激引起的疾病或病状的药物，尤其是神经退行性疾病，如阿尔茨海默病和帕金森病。
• Use of Collismycin and Derivatives Thereof as Oxidative Stress Inhibitors
  申请人：Martinez Gil Ana

  公开号：US20080275088A1

  公开（公告）日：2008-11-06

  The present invention relates to the use of Collismycin and derivatives thereof as inhibitors of oxidative stress in cells and their use for the preparation of medicaments for the treatment and/or prevention of oxidative stress-induced diseases or conditions, especially neurodegenerative diseases, such as Alzheimer's Disease and Parkinson's Disease.

  本发明涉及使用Collismycin及其衍生物作为细胞内氧化应激抑制剂及其用于制备治疗和/或预防氧化应激引起的疾病或症状的药物，特别是神经退行性疾病，如阿尔茨海默病和帕金森病。
• Use of collismycin and derivatives thereof as oxidative stress inhibitors
  申请人：Neuropharma S.A.

  公开号：EP1749552A1

  公开（公告）日：2007-02-07

  The present invention relates to the use of Collismycin and derivatives thereof as inhibitors of oxidative stress in cells and their use for the preparation of medicaments for the treatment of oxidative stress-induced diseases or conditions, specially neurodegenerative diseases, such as Alzheimer's Disease and Parkinson's Disease.

  本发明涉及科利霉素及其衍生物作为细胞氧化应激抑制剂的用途，以及它们用于制备治疗氧化应激引起的疾病或病症的药物，特别是神经退行性疾病，如阿尔茨海默氏症和帕金森氏症。
• Use of collismycin A as oxidative stress inhibitor
  申请人：NOSCIRA, S.A.

  公开号：EP1909912B1

  公开（公告）日：2012-06-06
• US8067441B2
  申请人：——

  公开号：US8067441B2

  公开（公告）日：2011-11-29