Allantodapsone | 6323-45-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: Allantodapsone
• 英文别名: 1-[[4-(4-aminophenyl)sulfonylanilino]methyl]-1,3-diazinane-2,4,5,6-tetrone
• CAS: 6323-45-1
• 化学式: C₁₇H₁₄N₄O₆S
• 分子量: 402.4
• InChiKey: JPOVFEACCADFBU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  164
• 氢给体数：
  3
• 氢受体数：
  8

文献信息

• Assays for identification of topoisomerase inhibitors
  申请人：Stivers T. James

  公开号：US20080020973A1

  公开（公告）日：2008-01-24

  The instant invention provides a continuous spectroscopic assay for DNA topoisomerase activity. The invention further provides topoisomerase inhibitors and pharmaceutical compositions for the treatment of topoisomerase associated diseases and disorders.
• COMBINATORIAL DRUG TREATMENT OF CANCER
  申请人：University of Virginia Patent Foundation

  公开号：US20220168329A1

  公开（公告）日：2022-06-02

  Described herein are methods for inhibiting protein arginine methyltransferase activity to create conditional vulnerability in tumors, thereby enhancing the effects of DNA damaging agents, methods of inhibiting tumor growth and/or reducing the volume of tumors using the same, and pharmaceutical compositions useful for carrying out the disclosed methods. In a further aspect, the methods and compositions disclosed herein exhibit synthetic lethality to tumor cells but produce few side effects.