N-(呋喃-2-甲基)4-氟苯磺酰胺 | 6341-35-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: N-(呋喃-2-甲基)4-氟苯磺酰胺
• 英文名称: 4-fluoro-N-(furan-2-ylmethyl)benzenesulfonamide
• CAS: 6341-35-1
• 化学式: C₁₁H₁₀FNO₃S
• mdl: MFCD01077680
• 分子量: 255.27
• InChiKey: YZOCTNGXNPMLGJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  67.7
• 氢给体数：
  1
• 氢受体数：
  5

安全信息

• 海关编码：
  2935009090

反应信息

• 作为反应物：
  描述：

  2-bromo-N-(tertbutyl)cyclopropanecarboxamide 、 N-(呋喃-2-甲基)4-氟苯磺酰胺 在 18-冠醚-6 、 potassium hydroxide 作用下， 以 四氢呋喃 为溶剂， 反应 12.0h， 以93%的产率得到N-(tert-butyl)-2-(4-fluoro-N-(furan-2-ylmethyl)phenylsulfonamido)cyclopropanecarboxamide
  参考文献：
  名称：

  Formal Substitution of Bromocyclopropanes with Nitrogen Nucleophiles

  摘要：

  A highly chemo- and diastereoselective protocol toward amino-substituted donor acceptor cyclopropanes via the formal nucleophilic displacement in bromocyclopropanes is described. A wide range of N-nucleophiles, including carboxamides, sulfonamides, azoles, and anilines, can be efficiently employed in this transformation, providing expeditious access to stereochemically defined and densely functionalized cydopropylamine derivatives.

  DOI：

  10.1021/jo4011798
• 作为产物：
  描述：

  2-呋喃甲胺 、 4-氟苯磺酰氯 以 二氯甲烷 为溶剂， 反应 2.0h， 以81%的产率得到N-(呋喃-2-甲基)4-氟苯磺酰胺
  参考文献：
  名称：

  Formal Substitution of Bromocyclopropanes with Nitrogen Nucleophiles

  摘要：

  A highly chemo- and diastereoselective protocol toward amino-substituted donor acceptor cyclopropanes via the formal nucleophilic displacement in bromocyclopropanes is described. A wide range of N-nucleophiles, including carboxamides, sulfonamides, azoles, and anilines, can be efficiently employed in this transformation, providing expeditious access to stereochemically defined and densely functionalized cydopropylamine derivatives.

  DOI：

  10.1021/jo4011798

文献信息

• Formal Substitution of Bromocyclopropanes with Nitrogen Nucleophiles
  作者：Joseph E. Banning、Jacob Gentillon、Pavel G. Ryabchuk、Anthony R. Prosser、Andrew Rogers、Andrew Edwards、Andrew Holtzen、Ivan A. Babkov、Marina Rubina、Michael Rubin

  DOI：10.1021/jo4011798

  日期：2013.8.2

  A highly chemo- and diastereoselective protocol toward amino-substituted donor acceptor cyclopropanes via the formal nucleophilic displacement in bromocyclopropanes is described. A wide range of N-nucleophiles, including carboxamides, sulfonamides, azoles, and anilines, can be efficiently employed in this transformation, providing expeditious access to stereochemically defined and densely functionalized cydopropylamine derivatives.