1-(1-ethyl-1H-benzimidazol-2-yl)methanamine | 883538-95-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 1-(1-ethyl-1H-benzimidazol-2-yl)methanamine
• 英文别名: (1-ethylbenzimidazol-2-yl)methanamine
• CAS: 883538-95-2
• 化学式: C₁₀H₁₃N₃
• mdl: MFCD06655844
• 分子量: 175.23
• InChiKey: JODSAKGGJDQULV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  43.8
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] BENZIMIDAZOLE ACETONITRILES<br/>[FR] BENZOXAZOLE ACÉTONITRILES
  申请人：APPLIED RESEARCH SYSTEMS

  公开号：WO2005026155A1

  公开（公告）日：2005-03-24

  The present invention is related to benzimidazole acetonitriles as well as to pharmaceutical formulations containing such benzimidazole acetonitriles of formula (I). Said benzimidazole acetonitriles are useful in the treatment of metabolic disorders mediated by insulin resistance or hyperglycemia, comprising diabetes type II, inadequate glucosetolerance, insulin resistance, obesity, polycystic ovary syndrome (PCOS) (I). The present invention is furthermore related to methods of preparing ben7.oxazole acetonitriles. G is pyrimidinyl; L is an amino group, or a 3-8 membered heterocycloalkyl, containing at least one heteroatorn selected from N, O, S or L is an acylamino moiety; R1 is selected from the group comprising or consisting of hydrogen, sulfonyl, amino, carboxy, aminocarbonyl, CI-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl or Cl-C6-alkoxy, aryl,halogen, cyano or hydroxy;R2 is selected from the group comprising or consisting of hydrogen, CI -C6-alkyl, C2-C6alkenyl, C2-C6-alkynyl, or CI -C6-alkoxy.

  本发明涉及苯并咪唑乙腈，以及含有该苯并咪唑乙腈的药物配方（I）的制备方法。所述苯并咪唑乙腈可用于治疗由胰岛素抵抗或高血糖介导的代谢紊乱，包括糖尿病II型、葡萄糖耐量不良、胰岛素抵抗、肥胖、多囊卵巢综合征（PCOS）。本发明还涉及制备苯7氧唑乙腈的方法。其中G为嘧啶基；L为氨基，或者含有至少一个来自N、O、S的杂原子的3-8成员杂环烷基，或者L为酰氨基基团；R1选自氢、磺酰基、氨基、羧基、氨基甲酰基、C1-C6烷基、C2-C6烯基、C2-C6炔基、或者C1-C6烷氧基的群；R2选自氢、C1-C6烷基、C2-C6烯基、C2-C6炔基、或者C1-C6烷氧基的群。