4-ethyl-N,N-dimethylpicolinamide | 42182-33-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4-ethyl-N,N-dimethylpicolinamide
• 英文别名: 4-Ethyl-2-N,N-dimethylcarboxamidopyridin；4-ethyl-pyridine-2-carboxylic acid dimethylamide；4-ethyl-N,N-dimethylpyridine-2-carboxamide
• CAS: 42182-33-2
• 化学式: C₁₀H₁₄N₂O
• 分子量: 178.234
• InChiKey: VNUUKJFVYZCKME-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  33.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-乙基吡啶 、 N,N-二甲基甲酰胺 在 dipotassium peroxodisulfate 作用下， 反应 12.0h， 以51%的产率得到4-ethyl-N,N-dimethylpicolinamide
  参考文献：
  名称：

  Transition-metal-free synthesis of primary to tertiary carboxamides: A quick access to prodrug-pyrazinecarboxamide

  摘要：

  One-pot expedient and direct carbamoylation of heterocyclics is described. The transformation is realized via direct dehydrogenative aminocarbonylation of heterocyclic compounds under transition-metal-free conditions. This method is regioselective and the protocol is proved to be scalable on a gram scale. Further, the therapeutically useful antitubercular agent pyrazinecarboxamide is successfully synthesized by employing this protocol. (C) 2017 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2017.11.006

文献信息

• HETEROCYCLYLAMINES AS PI3K INHIBITORS
  申请人：Li Yun-Long

  公开号：US20130059835A1

  公开（公告）日：2013-03-07

  The present invention provides heterocyclylamine derivatives of Formula I: wherein the variables are defined herein, that modulate the activity of phosphoinositide 3-kinases (PI3Ks) and are useful in the treatment of diseases related to the activity of PI3Ks including, for example, inflammatory disorders, immune-based disorders, cancer, and other diseases.

  本发明提供了式I的杂环胺衍生物： 其中变量如本文所定义，调节磷脂酰肌醇3-激酶（PI3Ks）的活性，并且在治疗与PI3Ks活性相关的疾病方面具有用处，例如炎症性疾病、免疫性疾病、癌症和其他疾病。
• Substituted Benzamide Compounds
  申请人：Reich Melanie

  公开号：US20120071461A1

  公开（公告）日：2012-03-22

  Substituted benzamide compounds corresponding to formula (I) in which R5, R6, R7, R8, a, b, c, d, t, D and X have defined meanings, a process for their preparation, pharmaceutical compositions comprising such compounds, and a method of using such compounds to treat pain and other conditions mediated at least in part via the bradykinin 1 receptor.

  对应于式(I)的取代苯甲酰胺化合物，其中R5、R6、R7、R8、a、b、c、d、t、D和X具有定义的含义，其制备方法，包括这些化合物的药物组合物，以及使用这些化合物治疗疼痛和其他至少部分通过激肽酶1受体介导的疾病的方法。
• Transition-metal-free synthesis of primary to tertiary carboxamides: A quick access to prodrug-pyrazinecarboxamide
  作者：Trimbak B. Mete、Ankit Singh、Ramakrishna G. Bhat

  DOI：10.1016/j.tetlet.2017.11.006

  日期：2017.12

  One-pot expedient and direct carbamoylation of heterocyclics is described. The transformation is realized via direct dehydrogenative aminocarbonylation of heterocyclic compounds under transition-metal-free conditions. This method is regioselective and the protocol is proved to be scalable on a gram scale. Further, the therapeutically useful antitubercular agent pyrazinecarboxamide is successfully synthesized by employing this protocol. (C) 2017 Elsevier Ltd. All rights reserved.