2-(3,5-bistrifluoromethylphenyl)-5-nitropyridine | 1357165-94-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-(3,5-bistrifluoromethylphenyl)-5-nitropyridine
• 英文别名: 2-[3,5-Bis(trifluoromethyl)phenyl]-5-nitropyridine；2-[3,5-bis(trifluoromethyl)phenyl]-5-nitropyridine
• CAS: 1357165-94-6
• 化学式: C₁₃H₆F₆N₂O₂
• 分子量: 336.193
• InChiKey: HTAMNEQNLKULBV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  23
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  58.7
• 氢给体数：
  0
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  iridium(III) chloride trihydrate 、 2-(3,5-bistrifluoromethylphenyl)-5-nitropyridine 以 乙二醇乙醚 、 水 为溶剂， 反应 24.0h， 以2.0475 g的产率得到
  参考文献：
  名称：

  Syntheses and characterizations of 5-nitro-2-(3′,5′-di(trifluoromethyl)phenyl)pyridyl-containing iridium(III) complexes and the two-band white photoluminescence properties in solution

  摘要：

  A derivative of 2-phenylpyridine (Hppy), 5-nitro-2-(3',5'-di(trifluoromethyl) phenyl) pyridine (HL), is prepared. The L-containing cyclometalated iridium(III) complexes with mono-and bidentate ancillary ligands, [Ir(L)(2)(PPh3)Cl] (1) and [Ir(L)(2)(pic)] (2, pic = picolinic acid), are synthesized and characterized. The photoluminescence (PL) spectra of 1 and 2 in CH2Cl2 solutions show emission maxima at 558 and 560 nm, corresponding to yellow light emission with the Commission Internationale de L'eclairage (CIE) coordinates of (0.45, 0.54) and (0.46, 0.52), respectively. However, the luminescence intensity of 2 with PL quantum yield of 0.71 is obviously stronger that of 1 with PLQY of 0.19. The two-band white PL properties of 2 and [Ir(dfppy)(2)(PPh3)(NCS)] (3, dfppy = 2-(4,6-difluorophenyl) pyridine) with efficient blue light emission are investigated. The CH2Cl2 solutions of 2 and 3 in the molar ratio of 1 : 5 show white light emission with the CIE coordinates of (0.33, 0.41).[GRAPHICS].

  DOI：

  10.1080/00958972.2016.1230671
• 作为产物：
  描述：

  2-氯-5-硝基吡啶 、 3,5-双(三氟甲基)苯硼酸 在 palladium diacetate 、 三苯基膦 、 potassium carbonate 作用下， 以 乙二醇二乙醚 、 水 为溶剂， 反应 24.33h， 以68.6%的产率得到2-(3,5-bistrifluoromethylphenyl)-5-nitropyridine
  参考文献：
  名称：

  Syntheses and characterizations of 5-nitro-2-(3′,5′-di(trifluoromethyl)phenyl)pyridyl-containing iridium(III) complexes and the two-band white photoluminescence properties in solution

  摘要：

  A derivative of 2-phenylpyridine (Hppy), 5-nitro-2-(3',5'-di(trifluoromethyl) phenyl) pyridine (HL), is prepared. The L-containing cyclometalated iridium(III) complexes with mono-and bidentate ancillary ligands, [Ir(L)(2)(PPh3)Cl] (1) and [Ir(L)(2)(pic)] (2, pic = picolinic acid), are synthesized and characterized. The photoluminescence (PL) spectra of 1 and 2 in CH2Cl2 solutions show emission maxima at 558 and 560 nm, corresponding to yellow light emission with the Commission Internationale de L'eclairage (CIE) coordinates of (0.45, 0.54) and (0.46, 0.52), respectively. However, the luminescence intensity of 2 with PL quantum yield of 0.71 is obviously stronger that of 1 with PLQY of 0.19. The two-band white PL properties of 2 and [Ir(dfppy)(2)(PPh3)(NCS)] (3, dfppy = 2-(4,6-difluorophenyl) pyridine) with efficient blue light emission are investigated. The CH2Cl2 solutions of 2 and 3 in the molar ratio of 1 : 5 show white light emission with the CIE coordinates of (0.33, 0.41).[GRAPHICS].

  DOI：

  10.1080/00958972.2016.1230671

文献信息

• Agent for Treatment of Eye Diseases
  申请人：Kakizuka Akira

  公开号：US20140148416A1

  公开（公告）日：2014-05-29

  The present invention provides agents effective to treat eye diseases, pharmaceutical compositions comprising them, methods for preparing pharmaceuticals for treatment of eye diseases comprising using the agents, use of the agents in manufacture of pharmaceuticals for treatment of eye diseases and methods for treating eye diseases comprising administering the agents or the pharmaceutical compositions. The eye diseases treated by the present invention include particularly glaucoma, especially normal tension glaucoma, or retinitis pigmentosa. The present invention provides the compound of formula (I) wherein R is as defined in the description.

  本发明提供了治疗眼部疾病的有效药剂，包括它们的制药组合物，制备用于治疗眼部疾病的药物的方法，包括使用这些药剂，以及在制造用于治疗眼部疾病的药物时使用这些药剂的方法，以及通过给药这些药剂或药物组合物来治疗眼部疾病的方法。本发明治疗的眼部疾病包括青光眼，特别是正常张力青光眼，或色素性视网膜病变。本发明提供了式（I）的化合物，其中R在说明中定义。
• Naphthalene Derivative
  申请人：Kakizuka Akira

  公开号：US20130184241A1

  公开（公告）日：2013-07-18

  The present invention provides compounds which can regulate VCP activity. The present invention provides the compound of formula (I) (R is as defined in the description) or oxides, esters, prodrugs, pharmaceutically acceptable salts or solvates thereof. The compounds can regulate VCP activity, and thus are useful for treating VCP-mediated diseases such as neurodegenerative diseases.

  本发明提供了可以调节VCP活性的化合物。本发明提供了式(I)的化合物（其中R如描述中所定义）或其氧化物、酯、前药、药学上可接受的盐或溶剂。这些化合物可以调节VCP活性，因此可用于治疗VCP介导的疾病，如神经退行性疾病。
• NAPHTHALENE DERIVATIVE
  申请人：Daito Chemix Corporation

  公开号：EP2599771B1

  公开（公告）日：2016-09-14
• AGENT FOR TREATMENT OF EYE DISEASES
  申请人：Daito Chemix Corporation

  公开号：EP2623494B1

  公开（公告）日：2015-09-02
• US9206129B2
  申请人：——

  公开号：US9206129B2

  公开（公告）日：2015-12-08