Diethyl 17-(4-methylphenyl)sulfonyl-1,9,17-triazatetracyclo[7.7.2.02,7.010,15]octadeca-2(7),3,5,10(15),11,13-hexaene-5,13-dicarboxylate | 1447826-50-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Diethyl 17-(4-methylphenyl)sulfonyl-1,9,17-triazatetracyclo[7.7.2.02,7.010,15]octadeca-2(7),3,5,10(15),11,13-hexaene-5,13-dicarboxylate
• 英文别名: diethyl 17-(4-methylphenyl)sulfonyl-1,9,17-triazatetracyclo[7.7.2.02,7.010,15]octadeca-2(7),3,5,10(15),11,13-hexaene-5,13-dicarboxylate
• CAS: 1447826-50-7
• 化学式: C₂₈H₂₉N₃O₆S
• 分子量: 535.621
• InChiKey: RIMRUFIIDMWKEF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  38
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  105
• 氢给体数：
  0
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  [(N-tosylimino)iodo]benzene 、 (+/-)-2,8-bis(ethoxycarbonyl)-6H,12H-5,11-methanodibenzo[b,f][1,5]diazocine 在 bis{rhodium[3,3'-(1,3-phenylene)bis(2,2-dimethylpropanoic acid)]} 作用下， 以 二氯甲烷 为溶剂， 反应 24.0h， 以77%的产率得到Diethyl 17-(4-methylphenyl)sulfonyl-1,9,17-triazatetracyclo[7.7.2.02,7.010,15]octadeca-2(7),3,5,10(15),11,13-hexaene-5,13-dicarboxylate
  参考文献：
  名称：

  Efficient Synthesis of Imino-methano Tröger Bases by Nitrene Insertions into C–N Bonds

  摘要：

  A direct nitrene insertion into C-N bonds is observed upon treatment of methano-Troger bases with arylsulfonyl iminophenyliodinanes under copper and dirhodium catalysis. Novel cyclic imino-methano Troger bases are obtained (55-88%). Enantiopure products (ee >= 99%) can be obtained with tailored substrates.

  DOI：

  10.1021/ol4016892

文献信息

• Efficient Synthesis of Imino-methano Tröger Bases by Nitrene Insertions into C–N Bonds
  作者：Sandip A. Pujari、Laure Guénée、Jérôme Lacour

  DOI：10.1021/ol4016892

  日期：2013.8.2

  A direct nitrene insertion into C-N bonds is observed upon treatment of methano-Troger bases with arylsulfonyl iminophenyliodinanes under copper and dirhodium catalysis. Novel cyclic imino-methano Troger bases are obtained (55-88%). Enantiopure products (ee >= 99%) can be obtained with tailored substrates.