4-(4,6-Diamino-[1,3,5]triazin-2-ylamino)-benzenethiol | 189297-50-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯硫酚类
• 英文名称: 4-(4,6-Diamino-[1,3,5]triazin-2-ylamino)-benzenethiol
• 英文别名: Benzenethiol, 4-[(4,6-diamino-1,3,5-triazin-2-yl)amino]-；4-[(4,6-diamino-1,3,5-triazin-2-yl)amino]benzenethiol
• CAS: 189297-50-5
• 化学式: C₉H₁₀N₆S
• 分子量: 234.285
• InChiKey: FRGKLWBPLYHSSX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  104
• 氢给体数：
  4
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  bis(4-melaminophenyl)disulfide 在 三丁基膦 作用下， 以 甲醇 、 水 为溶剂， 反应 1.0h， 生成 4-(4,6-Diamino-[1,3,5]triazin-2-ylamino)-benzenethiol
  参考文献：
  名称：

  The in vitro trypanocidal activity of organotin compounds

  摘要：

  A series of alkyl (aryl) thio organotin compounds were synthesized as potential trypanocidal drugs. These derivatives were prepared by the treatment of alkyl (or aryl) tin chlorides or oxides with thiols. Compounds were evaluated for trypanocidal activity using in vitro cultures of Trypanosoma equiperdum. Their efficiency for killing the parasites appeared to be under control of both the alkyl (or aryl) part of the molecule and the thio moiety. Several of the synthesized compounds exhibited a high in vitro levels of activity compared with the arsenic derivatives used for chemotherapy.

  DOI：

  10.1016/s0223-5234(97)87538-1

文献信息

• The in vitro trypanocidal activity of organotin compounds
  作者：J Susperregui、A Petsom、M Bayle、G Lain、C Giroud、T Baltz、G Déléris

  DOI：10.1016/s0223-5234(97)87538-1

  日期：1997.1

  A series of alkyl (aryl) thio organotin compounds were synthesized as potential trypanocidal drugs. These derivatives were prepared by the treatment of alkyl (or aryl) tin chlorides or oxides with thiols. Compounds were evaluated for trypanocidal activity using in vitro cultures of Trypanosoma equiperdum. Their efficiency for killing the parasites appeared to be under control of both the alkyl (or aryl) part of the molecule and the thio moiety. Several of the synthesized compounds exhibited a high in vitro levels of activity compared with the arsenic derivatives used for chemotherapy.