4'-chloro-2-methyl-3'-(trifluoromethyl)biphenyl | 893637-92-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4'-chloro-2-methyl-3'-(trifluoromethyl)biphenyl
• 英文别名: 1-Chloro-4-(2-methylphenyl)-2-(trifluoromethyl)benzene
• CAS: 893637-92-8
• 化学式: C₁₄H₁₀ClF₃
• 分子量: 270.682
• InChiKey: QAOLOFXFGKUUCJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  5-溴-2-氯三氟甲苯 、 2-甲基苯硼酸 在 potassium phosphate 、 四(三苯基膦)钯 作用下， 以 1,4-二氧六环 为溶剂， 反应 5.0h， 以96%的产率得到4'-chloro-2-methyl-3'-(trifluoromethyl)biphenyl
  参考文献：
  名称：

  Synthesis of trifluoromethyl-substituted bi- and terphenyls by site-selective Suzuki–Miyaura reactions of various dihalogenated trifluoromethyl-benzene derivatives

  摘要：

  A variety of trifluoromethylated bi- and terphenyls were prepared by site-selective Suzuki-Miyaura cross-coupling reactions of various dihalogenated trifluoromethyl-substituted benzene derivatives. The reactions proceed with excellent site-selectivities. (c) 2012 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jfluchem.2012.11.005

文献信息

• Synthesis of trifluoromethyl-substituted bi- and terphenyls by site-selective Suzuki–Miyaura reactions of various dihalogenated trifluoromethyl-benzene derivatives
  作者：Iftikhar Ali、Baraa Siyo、Zahid Hassan、Imran Malik、Ihsan Ullah、Asad Ali、Muhammad Nawaz、Jamshed Iqbal、Tamás Patonay、Alexander Villinger、Peter Langer

  DOI：10.1016/j.jfluchem.2012.11.005

  日期：2013.1

  A variety of trifluoromethylated bi- and terphenyls were prepared by site-selective Suzuki-Miyaura cross-coupling reactions of various dihalogenated trifluoromethyl-substituted benzene derivatives. The reactions proceed with excellent site-selectivities. (c) 2012 Elsevier B.V. All rights reserved.