2-(4-methoxyphenylamino)-3-(phenylsulfonyl)quinoxaline | 1203550-93-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2-(4-methoxyphenylamino)-3-(phenylsulfonyl)quinoxaline
• 英文别名: 3-(benzenesulfonyl)-N-(4-methoxyphenyl)quinoxalin-2-amine
• CAS: 1203550-93-9
• 化学式: C₂₁H₁₇N₃O₃S
• 分子量: 391.45
• InChiKey: SQOCSAJECQUUKR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  89.6
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2,3-二羟基喹喔啉 在 氯化亚砜 、 N,N-二甲基甲酰胺 作用下， 以 乙醇 、 甲苯 为溶剂， 反应 5.67h， 生成 2-(4-methoxyphenylamino)-3-(phenylsulfonyl)quinoxaline
  参考文献：
  名称：

  Synthesis and biological evaluation of novel 2-arylamino-3-(arylsulfonyl)quinoxalines as PI3Kα inhibitors

  摘要：

  A series of novel 2-arylamino-3-(arylsulfonyl)quinoxalines was synthesized through a newly developed approach. All synthesized target compounds were screened for their cytotoxicities against cancer cell lines including PC3, A549, HCT116, HL60 and KB. Representative compounds with favorable cytotoxicities were tested for their PI3K alpha inhibitory activities. Among the synthesized target compounds, 17 (PI3K alpha IC50: 0.07 mu M) displayed the most potent cellular activities (IC50 values of 0.14 mu M, 0.07 mu M, 0.95 mu M and 0.05 mu M against PC3, A549, HCT116 and HL 60, respectively). (C) 2011 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2011.09.015

文献信息

• Synthesis and biological evaluation of novel 2-arylamino-3-(arylsulfonyl)quinoxalines as PI3Kα inhibitors
  作者：Peng Wu、Yi Su、Xiaowen Liu、Lei Zhang、Yong Ye、Jianchao Xu、Shaoyu Weng、Yani Li、Tao Liu、Shufang Huang、Bo Yang、Qiaojun He、Yongzhou Hu

  DOI：10.1016/j.ejmech.2011.09.015

  日期：2011.11

  A series of novel 2-arylamino-3-(arylsulfonyl)quinoxalines was synthesized through a newly developed approach. All synthesized target compounds were screened for their cytotoxicities against cancer cell lines including PC3, A549, HCT116, HL60 and KB. Representative compounds with favorable cytotoxicities were tested for their PI3K alpha inhibitory activities. Among the synthesized target compounds, 17 (PI3K alpha IC50: 0.07 mu M) displayed the most potent cellular activities (IC50 values of 0.14 mu M, 0.07 mu M, 0.95 mu M and 0.05 mu M against PC3, A549, HCT116 and HL 60, respectively). (C) 2011 Elsevier Masson SAS. All rights reserved.