2',3'-Dichlor-4'-methoxy-2-phenylacetophenon | 59043-83-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 2',3'-Dichlor-4'-methoxy-2-phenylacetophenon
• 英文别名: 2,3-Dichlor-5-phenylacetyl-anisol；2,3-dichloro-4-phenylacetylanisole；1-(2,3-dichloro-4-methoxyphenyl)-2-phenylethanone
• CAS: 59043-83-3
• 化学式: C₁₅H₁₂Cl₂O₂
• 分子量: 295.165
• InChiKey: GMQPXSIUBYYIEO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2',3'-Dichlor-4'-methoxy-2-phenylacetophenon 在 硫酸 、 吡啶盐酸盐 、 乙酸酐 作用下， 以 四甲基甲烷二胺 为溶剂， 生成 2-phenyl-5-hydroxy-6,7-dichloro-1-indanone
  参考文献：
  名称：

  (1-Oxo-2-aryl or thienyl-2-substituted-5-indanyloxy (or thio) alkanoic

  摘要：

  本文披露了[1-氧代-2-芳基或噻吩基-2-取代-5-茚氧（或硫）]癸酸及其衍生物、盐、酯和酰胺。这些产物具有双重药用效果，表现出利尿、排盐和利尿酸排泄活性。同时还揭示了制备这种[1-氧代-2-芳基或噻吩基-2-取代-5-茚氧（或硫）]癸酸的方法、含有这些化合物的药物组合物以及包括使用这些化合物和组合物的治疗方法。

  公开号：

  US04096267A1
• 作为产物：
  描述：

  2,3-二氯茴香醚 、 苯乙酰氯 生成 2',3'-Dichlor-4'-methoxy-2-phenylacetophenon
  参考文献：
  名称：

  JOHNSON, P. C.;MATIER, W. L.

  摘要：

  DOI：

文献信息

• [1-Oxo-2-thienyl-2-substituted-5-indanyloxy (or thio)]alkanoic acids and
  申请人：Merck & Co., Inc.

  公开号：US04177285A1

  公开（公告）日：1979-12-04

  [1-Oxo-2-aryl or thienyl-2-substituted-5-indanyloxy (or thio)]alkaoic acid, derivatives thereof, their salts, esters and amides are disclosed. The products display a dual pharmaceutical utility in that they exhibit diuretic, saluretic and uricosuric activity. Also disclosed are processes for the preparation of such [1-oxo-2-aryl or thienyl-2-substituted-5-indanyloxy (or thio)]alkanoic acids, pharmaceutical compositions comprising therapeutically effective amounts of such compounds and methods of treatment comprising administering such compounds and compositions.

  本发明揭示了[1-氧代-2-芳基或噻吩基-2-取代-5-吲哚氧（或硫）基]脂肪酸及其衍生物、盐、酯和酰胺。该产品具有双重药物效用，表现出利尿、排盐和利尿酸活性。还揭示了制备这种[1-氧代-2-芳基或噻吩基-2-取代-5-吲哚氧（或硫）基]脂肪酸的方法、包含治疗有效量的这种化合物的药物组合物以及包括给予这种化合物和组合物的治疗方法。
• Tetrazole derivatives of [1-oxo-2-aryl or
  申请人：Merck & Co., Inc.

  公开号：US04182764A1

  公开（公告）日：1980-01-08

  [1-Oxo-2-aryl or thienyl-2-substituted-5-indanyloxy (or thio)]alkanoic acid, derivatives thereof, their salts, esters and amides are disclosed. The products display a dual pharmaceutical utility in that they exhibit diuretic, saluretic and uricosuric activity. Also disclosed are processes for the preparation of such [1-oxo-2-aryl or thienyl-2-substituted-5-indanyloxy (or thio)]alkanoic acids, pharmaceutical compositions comprising therapeutically effective amounts of such compounds and methods of treatment comprising administering such compounds and compositions.

  本发明揭示了[1-氧代-2-芳基或噻吩基-2-取代-5-茚氧(或硫)基]脂肪酸及其衍生物、盐、酯和酰胺。这些产物具有双重药用价值，因为它们表现出利尿、排盐和利尿酸作用。同时还揭示了制备这种[1-氧代-2-芳基或噻吩基-2-取代-5-茚氧(或硫)基]脂肪酸的方法、包含这些化合物的治疗有效量的制药组合物以及包括给予这些化合物和组合物的治疗方法。
• 6-Oxo-7-substituted and 7,7-disubstituted-6H-indeno-[5,4-b]furan (and
  申请人：Merck & Co., Inc.

  公开号：US03984552A1

  公开（公告）日：1976-10-05

  6-Oxo-7,7-disubstituted-1,2,7,8-tetrahydro (and 7,8-dihydro)-6H-indeno-[5,4-b]furan (and thiophene)carboxylic acids, the salt, ester and amide derivatives thereof and combinations of these compounds with antikaluretic agents are disclosed having diuretic-saluretic, uricosuric and antihypertensive activity.

  本发明公开了6-Oxo-7,7-二取代-1,2,7,8-四氢（和7,8-二氢）-6H-吲哚[5,4-b]呋喃（和噻吩）羧酸及其盐、酯和酰胺衍生物以及这些化合物与抗钾药物的组合物，具有利尿-排盐、尿酸排泄和降压活性。
• Silylated indanyloxyacetates
  申请人：Mead Johnson & Company

  公开号：US04291168A1

  公开（公告）日：1981-09-22

  Indanyloxy compounds having 2-alkynyl substituents which exhibit diuretic, saluretic, and uricosuric activity are described. The compounds are obtained according to a process involving selective etherification of a 5-hydroxyindanone followed by alkynylation with a silylated alkynyl bromide to provide novel silylated intermediates which are hydrolyzed to indanyloxy compounds such as (6,7-dichloro-1-oxo-2-phenyl-2-propargyl-5-indanyloxy)acetic acid.

  本文描述了具有2-炔基取代基的吲哚氧化物，具有利尿、盐利和尿酸排泄活性。该化合物通过一种选择性醚化5-羟基吲哚酮的过程获得，随后与硅化炔基溴化物进行炔基化反应，提供了新型的硅化中间体，这些中间体水解后可得到吲哚氧化物，例如（6,7-二氯-1-氧代-2-苯基-2-丙炔基-5-吲哚氧基）乙酸。
• 2-Alkynyl-5-indanyloxyacetic acids
  申请人：Mead Johnson & Company

  公开号：US04334088A1

  公开（公告）日：1982-06-08

  Indanyloxy compounds having 2-alkynyl substituents which exhibit diuretic, saluretic, and uricosuric activity are described. The compounds are obtained according to a process involving selective etherification of a 5-hydroxyindanone followed by alkynylation with a silylated alkynyl bromide to provide novel silylated intermediates which are hydrolyzed to indanyloxy compounds such as (6,7-dichloro-1-oxo-2-phenyl-2-propargyl-5-indanyloxy)acetic acid.

  本文描述了具有2-炔基取代基的Indanyloxy化合物，具有利尿、盐利和尿酸排泄活性。该化合物是通过选择性醚化5-羟基indanone的过程获得的，然后用硅化炔基溴化物进行炔基化，以提供新的硅化中间体，这些中间体被水解成Indanyloxy化合物，例如（6,7-二氯-1-氧代-2-苯基-2-丙炔基-5-Indanyloxy）乙酸。