2-Amino-4-p-tolyl-pyrimidine-5-carbonitrile | 264927-85-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2-Amino-4-p-tolyl-pyrimidine-5-carbonitrile
• 英文别名: 5-Pyrimidinecarbonitrile, 2-amino-4-(4-methylphenyl)-；2-amino-4-(4-methylphenyl)pyrimidine-5-carbonitrile
• CAS: 264927-85-7
• 化学式: C₁₂H₁₀N₄
• 分子量: 210.238
• InChiKey: COAYRLRQNGVLTG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  75.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  硝酸胍 、 3-(Dimethylamino)-2-(4-methylbenzoyl)acrylonitrile 在 potassium carbonate 作用下， 以 乙醇 为溶剂， 反应 10.0h， 以68%的产率得到2-Amino-4-p-tolyl-pyrimidine-5-carbonitrile
  参考文献：
  名称：

  Al-Shiekh, Mariam Abd Alha; Al-Zaydi, Khadijah Mohamed; Hafez, Ebtisam Abdel-Aziz, Journal of Chemical Research, Miniprint, 2000, # 1, p. 173 - 192

  摘要：

  DOI：

文献信息

• NEW SUBSTITUTED BIPHENYL ANALOGUES AS DUAL INHIBITORS OF AROMATASE AND SULFATASE
  申请人：BEAUFOUR IPSEN TIANJIN PHARMACEUTICAL CO., LTD

  公开号：US20170001964A1

  公开（公告）日：2017-01-05

  The present invention relates to new biphenyl derivatives of formula These compounds acting as aromatase and sulfatase inhibitors, they are particularly useful for treating pathological conditions or diseases in which aromatase and sulfatase are involved. Moreover, the present invention provides processes for the preparation of these compounds. The invention also relates to pharmaceutical compositions containing said products and their use for the preparation of a medicament, in particular for the treatment of diseases characterized by aromatase and sulfatase activity such as hormone-dependent cancers.
• US9682941B2
  申请人：——

  公开号：US9682941B2

  公开（公告）日：2017-06-20
• Al-Shiekh, Mariam Abd Alha; Al-Zaydi, Khadijah Mohamed; Hafez, Ebtisam Abdel-Aziz, Journal of Chemical Research, Miniprint, 2000, # 1, p. 173 - 192
  作者：Al-Shiekh, Mariam Abd Alha、Al-Zaydi, Khadijah Mohamed、Hafez, Ebtisam Abdel-Aziz

  DOI：——

  日期：——