1-<1-(6,7-dimethoxyphthalazin-1-yl)-4-piperidinyl>-1H-benzotriazole | 99161-40-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 1-<1-(6,7-dimethoxyphthalazin-1-yl)-4-piperidinyl>-1H-benzotriazole
• 英文别名: 1-[4-(1H-123-benzotriazol-1-yl)piperidin-1-yl]-6,7-dimethoxyphthalazine；1-[4-(Benzotriazol-1-yl)piperidin-1-yl]-6,7-dimethoxyphthalazine
• CAS: 99161-40-7
• 化学式: C₂₁H₂₂N₆O₂
• 分子量: 390.445
• InChiKey: JAQVTKSTLYMPIF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  29
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  78.2
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  1-(4-piperidinyl)-1H-benzotriazole 在 palladium on activated charcoal 氢气 、 potassium carbonate 、 potassium iodide 作用下， 以 溶剂黄146 、 N,N-二甲基甲酰胺 为溶剂， 40.0~100.0 ℃ 、101.33 kPa 条件下， 反应 18.0h， 生成 1-<1-(6,7-dimethoxyphthalazin-1-yl)-4-piperidinyl>-1H-benzotriazole
  参考文献：
  名称：

  Studies on cardiotonic agents. II. Synthesis of novel phthalazine and 1,2,3-benzotriazine derivatives.

  摘要：

  合成了一系列具有杂环基哌啶基的二氮杂萘和1,2,3-苯并三嗪衍生物，并测试了麻醉犬的强心活性。几种6, 7-二甲氧基酞嗪衍生物显示出与氨力农相当的相对有效的强心活性。

  DOI：

  10.1248/cpb.38.2179

文献信息

• NOMOTO, YUJI;OBASE, HIROYUKI;TAKAI, HARUKI;TERANISHI, MASAYUKI;NAKAMURA, +, CHEM. AND PHARM. BULL., 38,(1990) N, C. 2179-2183
  作者：NOMOTO, YUJI、OBASE, HIROYUKI、TAKAI, HARUKI、TERANISHI, MASAYUKI、NAKAMURA, +

  DOI：——

  日期：——
• EP1981868A2
  申请人：——

  公开号：EP1981868A2

  公开（公告）日：2008-10-22
• AMINOPHTHALAZINE DERIVATIVE COMPOUNDS
  申请人：Humphrey John Michael

  公开号：US20100222353A1

  公开（公告）日：2010-09-02

  The invention pertains to new aminophthalazine compounds that serve as effective phosphodiesterase (PDE) inhibitors. The invention also relates to compounds that are selective inhibitors of PDE-10. The invention further relates to intermediates for preparation of such compounds; pharmaceutical compositions comprising such compounds; and the use of such compounds in methods for treating certain central nervous system (CNS) or other disorders. The invention relates also to methods for treating neurodegenerative and psychiatric disorders, for example psychosis and disorders comprising deficient cognition as a symptom.
• [EN] AMINOPHTHALAZINE DERIVATIVE COMPOUNDS<br/>[FR] COMPOSES DERIVES D'AMINOPHTHALAZINE
  申请人：PFIZER PROD INC

  公开号：WO2007085954A2

  公开（公告）日：2007-08-02

  [EN] The invention pertains to new aminophthalazine compounds that serve as effective phosphodiesterase (PDE) inhibitors. The invention also relates to compounds that are selective inhibitors of PDE-10. The invention further relates to intermediates for preparation of such compounds; pharmaceutical compositions comprising such compounds; and the use of such compounds in methods for treating certain central nervous system (CNS) or other disorders. The invention relates also to methods for treating neurodegenerative and psychiatric disorders, for example psychosis and disorders comprising deficient cognition as a symptom.
  [FR] La présente invention concerne des composés d'aminophthalazine qui servent d'inhibiteurs effectifs de phosphodestérase (PDE). L'invention a aussi trait aux composés qui sont des inhibiteurs sélectifs de PDE-10. Elle concerne aussi des intermédiaires de préparation de tels composés, les compositions pharmaceutiques comprenant de tels composés et l'utilisation de tels composés dans des procédés de traitement de certains systèmes nerveux centraux (CNS) ou autres troubles. Cette invention a aussi trait à des procédés de traitement de troubles neurodégénératifs et psychiatriques, par exemple la psychose et les troubles comprenant des troubles cognitifs comme symptôme.
• Studies on cardiotonic agents. II. Synthesis of novel phthalazine and 1,2,3-benzotriazine derivatives.
  作者：Yuji NOMOTO、Hiroyuki OBASE、Haruki TAKAI、Masayuki TERANISHI、Joji NAKAMURA、Kazuhiro KUBO

  DOI：10.1248/cpb.38.2179

  日期：——

  A series of phthalazine and 1, 2, 3-benzotriazine derivatives which have heterocyclylpiperidino groups was synthesized and tested for cardiotonic activity in anesthetized dogs. Several 6, 7-dimethoxyphthalazine derivatives showed relatively potent cardiotonic activity comparable to that of amrinone.

  合成了一系列具有杂环基哌啶基的二氮杂萘和1,2,3-苯并三嗪衍生物，并测试了麻醉犬的强心活性。几种6, 7-二甲氧基酞嗪衍生物显示出与氨力农相当的相对有效的强心活性。