1-benzyl-6-methyl-1H-benzo[d][1,2,3]triazole | 1256156-88-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并三唑类
• 英文名称: 1-benzyl-6-methyl-1H-benzo[d][1,2,3]triazole
• 英文别名: 1-Benzyl-6-methylbenzotriazole
• CAS: 1256156-88-3
• 化学式: C₁₄H₁₃N₃
• 分子量: 223.277
• InChiKey: CVEOLJRVYWNLLM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  30.7
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  在 copper(l) iodide 、 potassium carbonate 作用下， 以 水 为溶剂， 反应 3.0h， 以85%的产率得到1-benzyl-6-methyl-1H-benzo[d][1,2,3]triazole
  参考文献：
  名称：

  A ligand-free copper (1) catalysed intramolecular N-arylation of diazoaminobenzenes in PEG-water: an expeditious protocol towards regiospecific 1-aryl benzotriazoles

  摘要：

  通过铜 (1) 催化 2-Haloaryldiazonium 盐的重氮氨基苯在 PEG 水中的分子内 N-芳基化反应，我们开发出了一种高效且用途广泛的方法，用于合成作为重要药用支架的各种区域特异性 1-芳基苯并三唑。该方法的主要特点是反应方案非常简单、可负担大量底物以及收率极高。

  DOI：

  10.1039/c0ob00177e

文献信息

• Generation of Arynes by Selective Cleavage of a Carbon–Phosphorus Bond of <i>o</i>-(Diarylphosphinyl)aryl Triflates Using a Grignard Reagent
  作者：Yoshitake Nishiyama、Shuhei Kamada、Suguru Yoshida、Takamitsu Hosoya

  DOI：10.1246/cl.180555

  日期：2018.9.5

  A novel method for generating arynes, including disubstituted benzynes and a dehydrophenoxathiin, is reported. The treatment of easily synthesizable o-(diarylphosphinyl)aryl triflates having two el...

  报道了一种用于生成芳烃的新方法，包括双取代苄和脱氢吩恶噻英。易于合成的邻（二芳基膦基）芳基三氟甲磺酸酯的处理，具有两个...
• Design and Application of New Imidazolylsulfonate-Based Benzyne Precursor: An Efficient Triflate Alternative
  作者：Szabolcs Kovács、Ádám I. Csincsi、Tibor Zs. Nagy、Sándor Boros、Géza Timári、Zoltán Novák

  DOI：10.1021/ol300529j

  日期：2012.4.20

  cycloadditions involving benzyne intermediates. The precursor offers an efficient alternative for generating benzynes compared to widely used ortho TMS triflates under similar reaction conditions. With the utilization of this new precursor, the formation of potentially genotoxic trifluoromethanesulfonate side product is eliminated. The applicability of the new benzyne precursor was demonstrated in different

  几种邻-（三甲基甲硅烷基）芳基咪唑基磺酸盐可以通过简单的方法合成，并成功地用于涉及苯炔中间体的环加成反应中。与在相似反应条件下广泛使用的邻位TMS三氟甲磺酸酯相比，该前体提供了生成苯炔的有效替代方法。通过使用这种新的前体，消除了潜在的具有遗传毒性的三氟甲磺酸盐副产物的形成。新型苯并炔前体的适用性已在不同类型的环加成反应制备杂环分子中得到证明。
• Nonaqueous electrolyte and nonaqueous secondary battery
  申请人：Asahi Kasei Kabushiki Kaisha

  公开号：US10756394B2

  公开（公告）日：2020-08-25

  The purpose of the present invention is to provide a nonaqueous electrolyte that contains acetonitrile having an excellent balance between viscosity and the dielectric constant and a fluorine-containing inorganic lithium salt, wherein the generation of complex cations comprising a transition metal and acetonitrile is suppressed, excellent load characteristics are exhibited, and increases in internal resistance upon repeated charge/discharge cycles are suppressed; a further purpose of the present invention is to provide a nonaqueous secondary battery. The present invention relates to a nonaqueous electrolyte which contains: a nonaqueous solvent comprising acetonitrile; a fluorine-containing inorganic lithium salt; and a specific nitrogenous cyclic compound typified by benzotriazole.

  本发明的目的是提供一种非水电解液，该电解液含有在粘度和介电常数之间具有极佳平衡的乙腈和含氟无机锂盐，其中包含过渡金属和乙腈的复合阳离子的生成受到抑制，显示出极佳的负载特性，并且在重复充放电循环中内阻的增加受到抑制；本发明的另一个目的是提供一种非水二次电池。本发明涉及一种非水电解液，其中包含：由乙腈组成的非水溶剂；含氟无机锂盐；以及以苯并三唑为典型代表的特定含氮环状化合物。
• Development and Application of <i>O</i>-(Trimethylsilyl)aryl Fluorosulfates for the Synthesis of Arynes
  作者：Qiao Chen、Hongmei Yu、Zhaoqing Xu、Li Lin、Xianxing Jiang、Rui Wang

  DOI：10.1021/acs.joc.5b00923

  日期：2015.7.2

  A class of o-(trimethylsilyl)aryl fluorosulfates was synthesized by a concise method and successfully used as aryne precursors for the first time. Different trapping agents such as azides, furans, and acyl acetoacetates could successfully react with the aryne precursors under mild conditions with good to excellent yields.
• [3 + 2] Cycloadditions of Azides with Arynes via Photolysis of Phthaloyl Peroxide Derivatives
  作者：Denghu Chang、Dan Zhu、Lei Shi

  DOI：10.1021/acs.joc.5b00517

  日期：2015.6.5

  Photolysis of phthaloyl peroxides yields arynes, which undergo [3 + 2] cycloadditions with azides. This reaction tolerates a variety of organic azides and phthaloyl peroxides and affords the corresponding benzotriazoles in moderate to good yields at room temperature.