[(R)-1-(2-Trimethylsilanyl-ethoxymethoxymethyl)-allyl]-carbamic acid benzyl ester | 444993-46-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [(R)-1-(2-Trimethylsilanyl-ethoxymethoxymethyl)-allyl]-carbamic acid benzyl ester
• 英文别名: benzyl N-[(2R)-1-(2-trimethylsilylethoxymethoxy)but-3-en-2-yl]carbamate
• CAS: 444993-46-8
• 化学式: C₁₈H₂₉NO₄Si
• 分子量: 351.518
• InChiKey: BOFUQBDCFACMGF-QGZVFWFLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  24
• 可旋转键数：
  12
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  56.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  [(R)-1-(2-Trimethylsilanyl-ethoxymethoxymethyl)-allyl]-carbamic acid benzyl ester 在 palladium diacetate 三丁基膦 、 二氮烯 、 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 [(R)-3-[4-[(R)-3-Benzyloxycarbonylamino-4-(2-trimethylsilanyl-ethoxymethoxy)-butyl]-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrrol-3-yl]-1-(2-trimethylsilanyl-ethoxymethoxymethyl)-propyl]-carbamic acid benzyl ester
  参考文献：
  名称：

  Heck reactions of amino acid building blocks: application to the synthesis of pyrrololine analogues

  摘要：

  Heck reactions of unsaturated amino acid building blocks are described which allow acess to homo- and bis-homophenylalanine derivatives and to gamma,delta-unsaturated amino acids. Preliminary synthetic studies utilising this chemistry for the preparation of pyrrololine and deoxypyrrololine analogues are also reported. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(02)00512-9
• 作为产物：
  描述：

  氯甲酸苄酯 在 sodium hydroxide 、 N,N-二异丙基乙胺 作用下， 以 水 为溶剂， 生成 [(R)-1-(2-Trimethylsilanyl-ethoxymethoxymethyl)-allyl]-carbamic acid benzyl ester
  参考文献：
  名称：

  Heck reactions of amino acid building blocks: application to the synthesis of pyrrololine analogues

  摘要：

  Heck reactions of unsaturated amino acid building blocks are described which allow acess to homo- and bis-homophenylalanine derivatives and to gamma,delta-unsaturated amino acids. Preliminary synthetic studies utilising this chemistry for the preparation of pyrrololine and deoxypyrrololine analogues are also reported. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(02)00512-9

文献信息

• Heck reactions of amino acid building blocks: application to the synthesis of pyrrololine analogues
  作者：Philip N. Collier、Ian Patel、Richard J.K. Taylor

  DOI：10.1016/s0040-4039(02)00512-9

  日期：2002.4

  Heck reactions of unsaturated amino acid building blocks are described which allow acess to homo- and bis-homophenylalanine derivatives and to gamma,delta-unsaturated amino acids. Preliminary synthetic studies utilising this chemistry for the preparation of pyrrololine and deoxypyrrololine analogues are also reported. (C) 2002 Elsevier Science Ltd. All rights reserved.