(R_p)-(2-mesyloxymethylphenyl)(phenyl)(trimethylsilylmethyl)phosphine-P-borane | 1620086-84-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (R_p)-(2-mesyloxymethylphenyl)(phenyl)(trimethylsilylmethyl)phosphine-P-borane
• 英文别名: [[2-(methylsulfonyloxymethyl)phenyl]-phenyl-(trimethylsilylmethyl)phosphaniumyl]boranuide
• CAS: 1620086-84-1
• 化学式: C₁₈H₂₈BO₃PSSi
• 分子量: 394.355
• InChiKey: YINAHRVOMMEIDD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  (R_p)-(2-mesyloxymethylphenyl)(phenyl)(trimethylsilylmethyl)phosphine-P-borane 在 lithium bromide 作用下， 以 四氢呋喃 为溶剂， 反应 2.5h， 以95%的产率得到(R_p)-(2-bromomethylphenyl)(phenyl)(trimethylsilylmethyl)phosphine-P-borane
  参考文献：
  名称：

  Efficient Asymmetric Syntheses of 1-Phenyl-phosphindane, Derivatives, and 2- or 3-Oxa Analogues: Mission Accomplished

  摘要：

  A highly enantioselective synthesis of unsubstituted 1-phenyl-phosphindane and its P-borane and P-oxide derivatives was effectively established via a new fluoride-triggered desilylative carbocyclization strategy. Preparation of the "oxygen atom-doped" 1-phenyl-3-oxa-1-phosphindane-P-borane analogue was otherwise achieved via a tandem P-alpha-iodination-intra-O-alkylation.

  DOI：

  10.1021/ol500970x
• 作为产物：
  描述：

  2-溴苄醇 在 硫酸 、 仲丁基锂 、 氯化铵 、 三乙胺 作用下， 以 四氢呋喃 、 甲醇 、 乙醚 、 二氯甲烷 、 水 为溶剂， 反应 11.75h， 生成 (R_p)-(2-mesyloxymethylphenyl)(phenyl)(trimethylsilylmethyl)phosphine-P-borane
  参考文献：
  名称：

  Efficient Asymmetric Syntheses of 1-Phenyl-phosphindane, Derivatives, and 2- or 3-Oxa Analogues: Mission Accomplished

  摘要：

  A highly enantioselective synthesis of unsubstituted 1-phenyl-phosphindane and its P-borane and P-oxide derivatives was effectively established via a new fluoride-triggered desilylative carbocyclization strategy. Preparation of the "oxygen atom-doped" 1-phenyl-3-oxa-1-phosphindane-P-borane analogue was otherwise achieved via a tandem P-alpha-iodination-intra-O-alkylation.

  DOI：

  10.1021/ol500970x

文献信息

• Efficient Asymmetric Syntheses of 1-Phenyl-phosphindane, Derivatives, and 2- or 3-Oxa Analogues: Mission Accomplished
  作者：Slavko Rast、Barbara Mohar、Michel Stephan

  DOI：10.1021/ol500970x

  日期：2014.5.16

  A highly enantioselective synthesis of unsubstituted 1-phenyl-phosphindane and its P-borane and P-oxide derivatives was effectively established via a new fluoride-triggered desilylative carbocyclization strategy. Preparation of the "oxygen atom-doped" 1-phenyl-3-oxa-1-phosphindane-P-borane analogue was otherwise achieved via a tandem P-alpha-iodination-intra-O-alkylation.