2-amino-4-(p-tolyl)-6-(p-tolylthio)pyridine-3,5-dicarbonitrile | 1413127-12-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-amino-4-(p-tolyl)-6-(p-tolylthio)pyridine-3,5-dicarbonitrile
• 英文别名: 2-amino-4-(4-methylphenyl)-6-(4-methylphenylsulfanyl)-3,5-pyridinedicarbonitrile；2-Amino-4-(4-methylphenyl)-6-(4-methylphenyl)sulfanylpyridine-3,5-dicarbonitrile；2-amino-4-(4-methylphenyl)-6-(4-methylphenyl)sulfanylpyridine-3,5-dicarbonitrile
• CAS: 1413127-12-4
• 化学式: C₂₁H₁₆N₄S
• 分子量: 356.451
• InChiKey: WTZOXGSOTHNNEN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  112
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  对甲基苯甲醛 在 copper(I) iodide 作用下， 以 乙醇 为溶剂， 反应 2.08h， 生成 2-amino-4-(p-tolyl)-6-(p-tolylthio)pyridine-3,5-dicarbonitrile
  参考文献：
  名称：

  CuI nanoparticles: a highly active and easily recyclable catalyst for the synthesis of 2-amino-3,5-dicyano-6-sulfanyl pyridines

  摘要：

  CuI nanoparticles as a worthwhile and reusable catalyst supply an eco-friendly procedure for the synthesis of 2-amino-3,5-dicyano-6-sulfanyl pyridine derivatives. The products were obtained in high yields and short reaction times via multicomponent reaction of aldehydes, malononitrile and thiols under reflux conditions. The method presented is mild, efficient, inexpensive and satisfactory to give the products in the presence of novel nanoscale materials.

  DOI：

  10.1080/17415993.2012.728220

文献信息

• Heterogeneous Cu(<scp>ii</scp>)/<scp>l</scp>-His@Fe₃O₄ nanocatalyst: a novel, efficient and magnetically-recoverable catalyst for organic transformations in green solvents
  作者：Masoomeh Norouzi、Arash Ghorbani-Choghamarani、Mohsen Nikoorazm

  DOI：10.1039/c6ra19776k

  日期：——

  A novel, efficient and green Cu(II)/L-His@Fe3O4 catalyst has been applied successfully in the synthesis of heterocyclic compounds. The resulting catalyst was used in the synthesis of 2,3-dihydroquinazolin-4(1H)-ones, polyhydroquinolines and 2-amino-6-(arylthio)pyridine-3,5-dicarbonitriles as biologically interesting compounds. The present research is focused on investigation of recycling, reusability

  一种新颖，高效，绿色的Cu（II）/ L- His @ Fe 3 O 4催化剂已成功用于杂环化合物的合成。所得催化剂用于合成2，3-二氢喹唑啉-4（1H）-酮，聚氢喹啉和2-氨基-6-（芳硫基）吡啶-3，5-二碳腈作为生物学上感兴趣的化合物。本研究的重点是研究相反应中催化剂的循环利用，可重复使用性和稳定性。Cu（II）/ L -His @ Fe 3 O 4该催化剂至少使用了六次，其活性与新鲜催化剂相当。通过TGA / DTG，EDS，XRD，VSM，FT-IR和SEM对催化剂的化学组成和结构进行了分析。
• Safaei-Ghomi, Javad; Ghasemzadeh, Mohammad Ali, Acta Chimica Slovenica, 2012, vol. 59, # 3, p. 697 - 702
  作者：Safaei-Ghomi, Javad、Ghasemzadeh, Mohammad Ali

  DOI：——

  日期：——