N-[2-(二甲氨基)乙基]-2-苯基乙酰胺 | 63224-23-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: N-[2-(二甲氨基)乙基]-2-苯基乙酰胺
• 中文别名: N-[2-(二甲基氨基)乙基]-苯乙酰胺
• 英文名称: N-[2-(dimethylamino)ethyl]-2-phenylacetamide
• 英文别名: phenyl-acetic acid-(2-dimethylamino-ethylamide)；Phenyl-essigsaeure-(2-dimethylamino-aethylamid)；Acetamide, N-(2-(dimethylamino)ethyl)-2-phenyl-
• CAS: 63224-23-7
• 化学式: C₁₂H₁₈N₂O
• mdl: MFCD01670646
• 分子量: 206.288
• InChiKey: SKGYVELDSNNACR-UHFFFAOYSA-N

物化性质

• 沸点：
  377.3±35.0 °C(Predicted)
• 密度：
  1.023±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.416
• 拓扑面积：
  32.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N-cyclohexyl-2-phenyl-acetamidine; hydrochloride 在 sodium hydroxide 、 硝基苯 、 苯 作用下， 生成 N-[2-(二甲氨基)乙基]-2-苯基乙酰胺
  参考文献：
  名称：

  174. Am。第十三部分。由取代的am和亚烷基二胺制备2-取代的4：5-二氢乙二醛和环同系物

  摘要：

  DOI：

  10.1039/jr9500000859

文献信息

• A convenient synthesis of amides from carboxylic acids and primary amines
  作者：J. Cossy、C. Pale-Grosdemange

  DOI：10.1016/s0040-4039(00)99121-4

  日期：1989.1

  A convenient method for the formation of carboxamides from carboxylic acids and primary amines in the presence of molecular sieves is described. This process is very chemoselective.

  描述了一种在分子筛存在下由羧酸和伯胺形成羧酰胺的简便方法。这个过程是非常化学选择性的。
• Anti-inflammatory 1-phenylethanolamine derivatives, pharmaceutical compositions thereof and processes for their manufacture
  申请人：IMPERIAL CHEMICAL INDUSTRIES PLC

  公开号：EP0000809A1

  公开（公告）日：1979-02-21

  The invention relates to topically anti-inflammatory 1-phenylethanolamine derivatives of the general formula I:- or acid-addition salts thereof, to pharmaceutical compositions thereof, and to analogy processes for their manufacture. A representative compound is 1-(4-amino -3,5- dichlorophenyl) -2- [1,1-dimethyl -2- (2-phenylacetamido) ethylamino] ethanol. The derivatives are useful in particular for the treatment of inflammatory diseases or conditions of the akin.

  本发明涉及通式 I：- 的局部抗炎 1-苯基乙醇胺衍生物或其酸加成盐，涉及其药物组合物，涉及其生产的类比工艺。 一个代表性的化合物是 1-（4-氨基-3,5-二氯苯基）-2-[1,1-二甲基-2-（2-苯基乙酰氨基）乙基氨基]乙醇。 这些衍生物特别适用于治疗炎症性疾病或类似疾病。
• Designing Anti-inflammatory Drugs from Parasitic Worms: A Synthetic Small Molecule Analogue of the <i>Acanthocheilonema viteae</i> Product ES-62 Prevents Development of Collagen-Induced Arthritis
  作者：Lamyaa Al-Riyami、Miguel A. Pineda、Justyna Rzepecka、Judith K. Huggan、Abedawn I. Khalaf、Colin J. Suckling、Fraser J. Scott、David T. Rodgers、Margaret M. Harnett、William Harnett

  DOI：10.1021/jm401251p

  日期：2013.12.27

  In spite of increasing evidence that parasitic worms may protect humans from developing allergic and autoimmune diseases and the continuing identification of defined helminth-derived immunomodulatory molecules, to date no new anti-inflammatory drugs have been developed from these organisms. We have approached this matter in a novel manner by synthesizing a library of drug-like small molecules based upon phosphorylcholine, the active moiety of the anti-inflammatory Acanthocheilonema viteae product, ES-62, which as an immunogenic protein is unsuitable for use as a drug. Following preliminary in vitro screening for inhibitory effects responses, a sulfone-containing phosphorylcholine analogue (11a) was selected for testing in collagen-induced arthritis (CIA). Testing revealed that 11a was as effective as ES-62 in protecting DBA/1 mice from developing CIA and mirrored its mechanism of action in downregulating the TLR/IL-1R transducer, MyD88. 11a is thus a novel prototype for anti-inflammatory drug development. on relevant macrophage cytokine an in vivo model of inflammation,
• HETEROCYCLIC COMPOUNDS, MEDICAMENTS CONTAINING SAID COMPOUNDS, USE THEREOF AND PROCESSES FOR THE PREPARATION THEREOF
  申请人：Boehringer Ingelheim International GmbH

  公开号：EP2794595B1

  公开（公告）日：2017-08-02
• 174. Amidines. Part XIII. Preparation of 2-substituted 4 : 5-dihydroglyoxalines and ring homologues from substituted amidines and alkylenediamines
  作者：P. Oxley、W. F. Short

  DOI：10.1039/jr9500000859

  日期：——