2-amino-4-(4-nitrophenyl)-6-(p-tolylthio)pyridine-3,5-dicarbonitrile | 1246280-34-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-amino-4-(4-nitrophenyl)-6-(p-tolylthio)pyridine-3,5-dicarbonitrile
• 英文别名: 2-Amino-6-(4-methylphenyl)sulfanyl-4-(4-nitrophenyl)pyridine-3,5-dicarbonitrile；2-amino-6-(4-methylphenyl)sulfanyl-4-(4-nitrophenyl)pyridine-3,5-dicarbonitrile
• CAS: 1246280-34-1
• 化学式: C₂₀H₁₃N₅O₂S
• 分子量: 387.422
• InChiKey: GJXQOKCDGYFGLP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  28
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  158
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  对硝基苯甲醛 在 copper(I) iodide 作用下， 以 乙醇 为溶剂， 反应 1.67h， 生成 2-amino-4-(4-nitrophenyl)-6-(p-tolylthio)pyridine-3,5-dicarbonitrile
  参考文献：
  名称：

  CuI nanoparticles: a highly active and easily recyclable catalyst for the synthesis of 2-amino-3,5-dicyano-6-sulfanyl pyridines

  摘要：

  CuI nanoparticles as a worthwhile and reusable catalyst supply an eco-friendly procedure for the synthesis of 2-amino-3,5-dicyano-6-sulfanyl pyridine derivatives. The products were obtained in high yields and short reaction times via multicomponent reaction of aldehydes, malononitrile and thiols under reflux conditions. The method presented is mild, efficient, inexpensive and satisfactory to give the products in the presence of novel nanoscale materials.

  DOI：

  10.1080/17415993.2012.728220

文献信息

• SnO nanoparticles as an efficient catalyst for the one-pot synthesis of chromeno[2,3-b]pyridines and 2-amino-3,5-dicyano-6-sulfanyl pyridines
  作者：Javad Safaei-Ghomi、Hossein Shahbazi-Alavi、Elham Heidari-Baghbahadorani

  DOI：10.1039/c4ra04769a

  日期：——

  SnO nanoparticles have been used as an efficient catalyst for the preparation of chromeno[2,3-b]pyridines and 2-amino-3,5-dicyano-6-sulfanyl pyridines under reflux conditions in ethanol in good to excellent yields. This flexible and nano-catalytic procedure showed good recyclability and provides a clean condensation reaction in a short reaction time.

  SnO纳米颗粒已被用作高效的催化剂，用于在乙醇中回流条件下以良好至极好的收率制备苯并[2,3- b ]吡啶和2-氨基-3,5-二氰基-6-硫烷基吡啶。这种灵活的纳米催化程序显示出良好的可回收性，并在较短的反应时间内提供了干净的缩合反应。
• Propylphosphonium hydrogen carbonate ionic liquid supported on nano-silica as a reusable catalyst for the efficient multicomponent synthesis of fully substituted pyridines and bis-pyridines
  作者：Fahime Rahmani、Iraj Mohammadpoor-Baltork、Ahmad R. Khosropour、Majid Moghadam、Shahram Tangestaninejad、Valiollah Mirkhani

  DOI：10.1039/c5ra03569d

  日期：——

  (PPHC–nSiO2), was prepared and characterized by FT-IR, TGA, SEM and ICP techniques. The resulting catalyst was used for the efficient synthesis of fully substituted pyridines via a one-pot multicomponent reaction of aldehydes, malononitrile, and thiols under solvent-free conditions. Expedient synthesis of bis-pyridines from dialdehydes and/or dithiols by using this catalytic system can be considered

  制备了一种新型的负载型based基离子液体，载于纳米二氧化硅（PPHC- n SiO 2）上的碳酸氢丙propyl离子液体，并通过FT-IR，TGA，SEM和ICP技术进行了表征。通过在无溶剂条件下醛，丙二腈和硫醇的一锅多组分反应，将所得催化剂用于有效合成全取代的吡啶。通过使用该催化体系由二醛和/或二硫醇方便地合成双吡啶可被认为是该方法的显着优点。此外，即使在第5个循环后也没有明显的催化活性损失。
• Safaei-Ghomi, Javad; Ghasemzadeh, Mohammad Ali, Acta Chimica Slovenica, 2012, vol. 59, # 3, p. 697 - 702
  作者：Safaei-Ghomi, Javad、Ghasemzadeh, Mohammad Ali

  DOI：——

  日期：——
• CuI nanoparticles: a highly active and easily recyclable catalyst for the synthesis of 2-amino-3,5-dicyano-6-sulfanyl pyridines
  作者：Javad Safaei-Ghomi、Mohammad Ali Ghasemzadeh

  DOI：10.1080/17415993.2012.728220

  日期：2013.6.1

  CuI nanoparticles as a worthwhile and reusable catalyst supply an eco-friendly procedure for the synthesis of 2-amino-3,5-dicyano-6-sulfanyl pyridine derivatives. The products were obtained in high yields and short reaction times via multicomponent reaction of aldehydes, malononitrile and thiols under reflux conditions. The method presented is mild, efficient, inexpensive and satisfactory to give the products in the presence of novel nanoscale materials.