(2'R,5'R,1''R)-2-[1''-(tert-butyldimethylsilyloxy)-2'',2''-dimethylpropyl]-6-[(2',5'-dimethylpyrrolidin-1-yl)methyl]pyridine | 353495-93-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: (2'R,5'R,1''R)-2-[1''-(tert-butyldimethylsilyloxy)-2'',2''-dimethylpropyl]-6-[(2',5'-dimethylpyrrolidin-1-yl)methyl]pyridine
• 英文别名: tert-butyl-[(1R)-1-[6-[[(2R,5R)-2,5-dimethylpyrrolidin-1-yl]methyl]pyridin-2-yl]-2,2-dimethylpropoxy]-dimethylsilane
• CAS: 353495-93-9
• 化学式: C₂₃H₄₂N₂OSi
• 分子量: 390.685
• InChiKey: ZUJXVNDGQLGUMM-OPYAIIAOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.56
• 重原子数：
  27
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  25.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (2'R,5'R,1''R)-2-[1''-(tert-butyldimethylsilyloxy)-2'',2''-dimethylpropyl]-6-[(2',5'-dimethylpyrrolidin-1-yl)methyl]pyridine 在 盐酸 作用下， 反应 30.0h， 以71%的产率得到(2'R,5'R,1''R)-2-[(2',5'-dimethylpyrrolidin-1-yl)methyl]-6-(1''-hydroxy-2'',2''-dimethylpropyl)pyridine
  参考文献：
  名称：

  Pyrrolidinopyridines in Palladium-Catalyzed Allylic Substitutions − Conformation of the Ligand

  摘要：

  The (R,R)-2-[(2,5-dimethylpyrrolidin-1-yl)methyl]pyridines 4, 5, and 6 carrying a 2-hydroxyalkyl, 2-alkoxyalkyl or 2-siloxyalkyl substituent in the 6-position of the pyridine ring were prepared and assessed in palladium-catalyzed allylations of 1,3-diphenylpropenyl acetate with malonate. All ligands having g-substituents with an S absolute configuration afforded the product with an R configuration in 80-84% ee, whereas those having substituents with an R absolute configuration gave the opposite product with a selectivity depending on the nature of the substituent (8-74% ee). It is believed that the enantioselectivity is dependent on the conformation of that substituent.

  DOI：

  10.1002/1099-0690(200106)2001:11<2191::aid-ejoc2191>3.0.co;2-x
• 作为产物：
  描述：

  (1'R)-6-bromo-2-[1'-(tert-butyldimethylsilyloxy)-2',2'-dimethylpropyl]pyridine 在 正丁基锂 、 三乙胺 、 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 、 various solvents 、 乙腈 为溶剂， 反应 67.33h， 生成 (2'R,5'R,1''R)-2-[1''-(tert-butyldimethylsilyloxy)-2'',2''-dimethylpropyl]-6-[(2',5'-dimethylpyrrolidin-1-yl)methyl]pyridine
  参考文献：
  名称：

  Pyrrolidinopyridines in Palladium-Catalyzed Allylic Substitutions − Conformation of the Ligand

  摘要：

  The (R,R)-2-[(2,5-dimethylpyrrolidin-1-yl)methyl]pyridines 4, 5, and 6 carrying a 2-hydroxyalkyl, 2-alkoxyalkyl or 2-siloxyalkyl substituent in the 6-position of the pyridine ring were prepared and assessed in palladium-catalyzed allylations of 1,3-diphenylpropenyl acetate with malonate. All ligands having g-substituents with an S absolute configuration afforded the product with an R configuration in 80-84% ee, whereas those having substituents with an R absolute configuration gave the opposite product with a selectivity depending on the nature of the substituent (8-74% ee). It is believed that the enantioselectivity is dependent on the conformation of that substituent.

  DOI：

  10.1002/1099-0690(200106)2001:11<2191::aid-ejoc2191>3.0.co;2-x

文献信息

• Pyrrolidinopyridines in Palladium-Catalyzed Allylic Substitutions − Conformation of the Ligand
  作者：Robert Stranne、Christina Moberg

  DOI：10.1002/1099-0690(200106)2001:11<2191::aid-ejoc2191>3.0.co;2-x

  日期：2001.6

  The (R,R)-2-[(2,5-dimethylpyrrolidin-1-yl)methyl]pyridines 4, 5, and 6 carrying a 2-hydroxyalkyl, 2-alkoxyalkyl or 2-siloxyalkyl substituent in the 6-position of the pyridine ring were prepared and assessed in palladium-catalyzed allylations of 1,3-diphenylpropenyl acetate with malonate. All ligands having g-substituents with an S absolute configuration afforded the product with an R configuration in 80-84% ee, whereas those having substituents with an R absolute configuration gave the opposite product with a selectivity depending on the nature of the substituent (8-74% ee). It is believed that the enantioselectivity is dependent on the conformation of that substituent.