4-(furan-3-yl)butanoic acid | 1250265-39-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 杂芳族化合物
• 英文名称: 4-(furan-3-yl)butanoic acid
• 英文别名: 4-(3-furyl)butanoic acid；4-(Furan-3-yl)butanoic acid
• CAS: 1250265-39-4
• 化学式: C₈H₁₀O₃
• 分子量: 154.166
• InChiKey: XEFVKFZSTNIZEE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  50.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-(furan-3-yl)butanoic acid 在 草酰氯 、 N,N-二甲基甲酰胺 、 四氯化锡 作用下， 以 二氯甲烷 为溶剂， 反应 3.0h， 以4.478 g的产率得到5,6-二氢苯并呋喃-7(4h)-酮
  参考文献：
  名称：

  Furan Approach to Vitamin D Analogues. Synthesis of the A-Ring of Calcitriol and 1α-Hydroxy-3-deoxyvitamin D₃

  摘要：

  The A-rings of calcitriol (1 alpha,25-dihydeoxyvitamin D-3) and 1 alpha-hydroxy-3-deoxyvitamin D-3 were synthesized using the furan approach The critical steps in the synthesis of the A-ring of calcitriol involved an asymmetric carbonyl-ene reaction of 3-methylene-2,3-dihydrofuran with 3-(tert-butyldimethylsiloxy)-propanal. a diostereoselective Friedel-Crafts hydroxyalkylation an oxidation of the 2.3-disubstituted furan to give a gamma-hydroxybutenolide and a Peterson olefinatiion The A-ring (Z)-dienol of calcitriol was synthesized in 12 steps from 3-(tert-butyldimethylsiloxy)propanal in 17% yield

  DOI：

  10.1021/jo101155c
• 作为产物：
  描述：

  ethyl 4-(furan-3-yl)butanoate 在 potassium hydroxide 、 盐酸 作用下， 以 乙醇 、 水 为溶剂， 反应 1.5h， 以93%的产率得到4-(furan-3-yl)butanoic acid
  参考文献：
  名称：

  Furan Approach to Vitamin D Analogues. Synthesis of the A-Ring of Calcitriol and 1α-Hydroxy-3-deoxyvitamin D₃

  摘要：

  The A-rings of calcitriol (1 alpha,25-dihydeoxyvitamin D-3) and 1 alpha-hydroxy-3-deoxyvitamin D-3 were synthesized using the furan approach The critical steps in the synthesis of the A-ring of calcitriol involved an asymmetric carbonyl-ene reaction of 3-methylene-2,3-dihydrofuran with 3-(tert-butyldimethylsiloxy)-propanal. a diostereoselective Friedel-Crafts hydroxyalkylation an oxidation of the 2.3-disubstituted furan to give a gamma-hydroxybutenolide and a Peterson olefinatiion The A-ring (Z)-dienol of calcitriol was synthesized in 12 steps from 3-(tert-butyldimethylsiloxy)propanal in 17% yield

  DOI：

  10.1021/jo101155c

文献信息

• PROTEIN AND PEPTIDE LIBRARIES
  申请人：Treco Douglas A.

  公开号：US20140234898A1

  公开（公告）日：2014-08-21

  Provided herein are, inter alia, methods for linking an mRNA molecule to a polypeptide (e.g., a peptide or a protein) by linking the mRNA molecule to a linking amino acid in the polypeptide, or by linking the mRNA molecule to a linking tRNA to which the polypeptide is attached, via reactions not catalyzed by the ribosome, and methods for making polypeptide libraries. Also provided are mRNA-protein complexes and mRNA-tRNA-protein complexes, libraries containing these complexes, and methods of using these complexes.

  本文提供了将mRNA分子与多肽（例如肽或蛋白质）连接的方法，其中通过将mRNA分子连接到多肽中的连接氨基酸，或通过将mRNA分子连接到连接tRNA，再将tRNA连接到多肽上，通过非核糖体催化的反应实现连接。同时，还提供了制备多肽库的方法。此外，本文还提供了mRNA-蛋白质复合物和mRNA-tRNA-蛋白质复合物，以及包含这些复合物的库以及使用这些复合物的方法。
• US9422550B2
  申请人：——

  公开号：US9422550B2

  公开（公告）日：2016-08-23
• [EN] PROTEIN AND PEPTIDE LIBRARIES<br/>[FR] BANQUES DE PROTÉINES ET DE PEPTIDES
  申请人：GEN HOSPITAL CORP

  公开号：WO2013019794A1

  公开（公告）日：2013-02-07

  Provided herein are, inter alia, methods for linking an mRNA molecule to a polypeptide (e.g., a peptide or a protein) by linking the mRNA molecule to a linking amino acid in the polypeptide, or by linking the mRNA molecule to a linking tRNA to which the polypeptide is attached, via reactions not catalyzed by the ribosome, and methods for making polypeptide libraries. Also provided are mRNA-protein complexes and mRNA-tRNA-protein complexes, libraries containing these complexes, and methods of using these complexes.
• [EN] COMBINATION OF INTRACELLULAR AND EXTRACELLULAR PHOTOSENSITIZERS FOR TREATMENT OF BACTERIAL INFECTION<br/>[FR] COMBINAISON DE PHOTOSENSIBILISATEURS INTRACELLULAIRE ET EXTRACELLULAIRE DE TRAITEMENT D'UNE INFECTION BACTÉRIENNE
  申请人：[en]VANDERBILT UNIVERSITY

  公开号：WO2022165023A1

  公开（公告）日：2022-08-04

  A method of inducing death or inhibiting growth or reproduction of a Gram-positive bacterial cell involves contacting the bacterial cell with a coproporphyrinogen oxidase (CgoX) activator, thereby promoting accumulation of coproporphyrin III (CPIII) in the bacterial cell, where the CPIII serves as an intracellular photosensitizer; contacting the bacterial cell with a photosensitizer conjugated to an iron-regulated surface determinant (Isd) protein targeting moiety, which Isd proteins are expressed on the service of the bacterial cell such that the conjugated photosensitizer serves as an extracellular photosensitizer; exposing the bacterial cell to light having a first excitation wavelength of the intracellular photosensitizer; and exposing the bacterial cell to light having a second excitation wavelength of the extracellular photosensitizer.
• Furan Approach to Vitamin D Analogues. Synthesis of the A-Ring of Calcitriol and 1α-Hydroxy-3-deoxyvitamin D₃
  作者：William H. Miles、Katelyn B. Connell、Gözde Ulas、Hannah H. Tuson、Elizabeth A. Dethoff、Varun Mehta、April J. Thrall

  DOI：10.1021/jo101155c

  日期：2010.10.15

  The A-rings of calcitriol (1 alpha,25-dihydeoxyvitamin D-3) and 1 alpha-hydroxy-3-deoxyvitamin D-3 were synthesized using the furan approach The critical steps in the synthesis of the A-ring of calcitriol involved an asymmetric carbonyl-ene reaction of 3-methylene-2,3-dihydrofuran with 3-(tert-butyldimethylsiloxy)-propanal. a diostereoselective Friedel-Crafts hydroxyalkylation an oxidation of the 2.3-disubstituted furan to give a gamma-hydroxybutenolide and a Peterson olefinatiion The A-ring (Z)-dienol of calcitriol was synthesized in 12 steps from 3-(tert-butyldimethylsiloxy)propanal in 17% yield