tert-butyl (4'-formyl-[1,1'-biphenyl]-3-yl)carbamate | 398150-60-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: tert-butyl (4'-formyl-[1,1'-biphenyl]-3-yl)carbamate
• 英文别名: tert-Butyl (4'-formylbiphenyl-3-yl)carbamate；Tert-butyl (4'-formyl-biphenyl-3-yl)carbamate；tert-butyl N-[3-(4-formylphenyl)phenyl]carbamate
• CAS: 398150-60-2
• 化学式: C₁₈H₁₉NO₃
• 分子量: 297.354
• InChiKey: VTDHZHFRVZTKQW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  55.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  tert-butyl (4'-formyl-[1,1'-biphenyl]-3-yl)carbamate 在 哌啶 、 potassium carbonate 作用下， 以 乙醇 、 乙腈 为溶剂， 生成 tert-butyl (4'-(2-(benzylthio)-5-cyano-6-oxo-1,6-dihydropyrimidin-4-yl)-[1,1'-biphenyl]-3-yl)carbamate
  参考文献：
  名称：

  Design, syntheses and evaluation of 4-oxo-5-cyano thiouracils as SecA inhibitors

  摘要：

  Protein translocation is essential for bacterial survival and the most important translocation mechanism is the secretion (Sec) pathway in which SecA is a central core driving force. Thus targeting SecA is a promising strategy for developing novel antibacterial therapeutics. Herein, we report the syntheses and evaluation of a series of nearly 60 4-oxo-5-cyano thiouracil derivatives based upon our previously reported core pyrimidine structure. Introduction of polar group such as -N-3 and linker groups such as -CH2-O- enhanced the potency several fold. Apart from being potential antibacterial agents, these inhibitors can be indispensable tools for biologists to probe the mechanism of protein translocation via the SecA machinery in bacteria. Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmc.2014.11.017
• 作为产物：
  描述：

  对溴苯甲醛 、 3-BOC-氨基苯基硼酸 在 potassium carbonate 、 四(三苯基膦)钯 作用下， 以 乙醇 、 水 、 甲苯 为溶剂， 反应 0.41h， 以58%的产率得到tert-butyl (4'-formyl-[1,1'-biphenyl]-3-yl)carbamate
  参考文献：
  名称：

  [EN] PENTAFLUOROPHENYL SULFONAMIDE COMPOUNDS, COMPOSITIONS AND USES THEREOF
  [FR] COMPOSÉS DE SULFONAMIDE PENTAFLUOROPHÉNYLE, COMPOSITIONS ET UTILISATIONS ASSOCIÉES

  摘要：

  本申请涉及含有化合物的磺胺基的化合物的公式（I）和（II），以及含有该化合物的组合物，对细胞增殖性疾病，特别是癌症的治疗有效，并且相关的各种使用方法。

  公开号：

  WO2019056120A1

文献信息

• Biaromatic compound activators of PPARy-type receptors
  申请人：GALDERMA RESEARCH & DEVELOPMENT S.N.C.

  公开号：US20040039038A1

  公开（公告）日：2004-02-26

  The invention relates to novel biaromatic compounds which correspond to the general formula (I) below: 1 and also to the method for preparing them and their use in pharmaceutical compositions intended for use in human or veterinary medicine (in dermatology, and also in the field of cardiovascular diseases, immune diseases and/or diseases associated with lipid metabolism), or alternatively in cosmetic compositions.

  这项发明涉及与下面的一般公式（I）相对应的新型双芳香化合物：1，以及制备它们的方法和它们在用于人类或兽医医学（在皮肤病学领域，以及心血管疾病、免疫疾病和/或与脂质代谢相关的疾病）的药物组合物中的用途，或者在化妆品组合物中的用途。
• Biaromatic compound activators of PPARγ-type receptors
  申请人：Bernardon Jean-Michael

  公开号：US06927228B2

  公开（公告）日：2005-08-09

  The invention relates to novel biaromatic compounds which correspond to the general formula (I) below: and also to the method for preparing them and their use in pharmaceutical compositions intended for use in human or veterinary medicine (in dermatology, and also in the field of cardiovascular diseases, immune diseases and/or diseases associated with lipid metabolism), or alternatively in cosmetic compositions.

  本发明涉及一种新型的双芳基化合物，其符合以下通式（I）：还涉及制备它们的方法以及它们在制药组合物中的使用，该组合物用于人类或兽医学（在皮肤病学，心血管疾病领域，免疫疾病和/或与脂质代谢相关的疾病），或者用于化妆品组合物。
• Design, syntheses and evaluation of 4-oxo-5-cyano thiouracils as SecA inhibitors
  作者：Arpana S. Chaudhary、Jinshan Jin、Weixuan Chen、Phang C. Tai、Binghe Wang

  DOI：10.1016/j.bmc.2014.11.017

  日期：2015.1

  Protein translocation is essential for bacterial survival and the most important translocation mechanism is the secretion (Sec) pathway in which SecA is a central core driving force. Thus targeting SecA is a promising strategy for developing novel antibacterial therapeutics. Herein, we report the syntheses and evaluation of a series of nearly 60 4-oxo-5-cyano thiouracil derivatives based upon our previously reported core pyrimidine structure. Introduction of polar group such as -N-3 and linker groups such as -CH2-O- enhanced the potency several fold. Apart from being potential antibacterial agents, these inhibitors can be indispensable tools for biologists to probe the mechanism of protein translocation via the SecA machinery in bacteria. Published by Elsevier Ltd.
• [EN] PENTAFLUOROPHENYL SULFONAMIDE COMPOUNDS, COMPOSITIONS AND USES THEREOF<br/>[FR] COMPOSÉS DE SULFONAMIDE PENTAFLUOROPHÉNYLE, COMPOSITIONS ET UTILISATIONS ASSOCIÉES
  申请人：DALRIADA THERAPEUTICS INC

  公开号：WO2019056120A1

  公开（公告）日：2019-03-28

  The present application relates to sulfonamide containing compounds of Formulae (I) and (II) and compositions containing said compounds effective in the treatment of cell proliferative disorders, in particular cancer, and various methods of use thereof.

  本申请涉及含有化合物的磺胺基的化合物的公式（I）和（II），以及含有该化合物的组合物，对细胞增殖性疾病，特别是癌症的治疗有效，并且相关的各种使用方法。