3-(3-(5-(4-Methyl-benzyl)-thiophen-2-ylmethyl)-isoxazol-5-yl)-pyridin-2-ylamine | 936340-66-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 3-(3-(5-(4-Methyl-benzyl)-thiophen-2-ylmethyl)-isoxazol-5-yl)-pyridin-2-ylamine
• 英文别名: 3-[3-[[5-[(4-Methylphenyl)methyl]thiophen-2-yl]methyl]-1,2-oxazol-5-yl]pyridin-2-amine
• CAS: 936340-66-8
• 化学式: C₂₁H₁₉N₃OS
• 分子量: 361.467
• InChiKey: IGOSGBUWRIIEDY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  93.2
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  5-(4-(methyl-benzyl)-5-thiophen-2-yl)-acetohydroximoyl chloride 、 3-乙炔吡啶-2-胺 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 2.0h， 以18.1%的产率得到3-(3-(5-(4-Methyl-benzyl)-thiophen-2-ylmethyl)-isoxazol-5-yl)-pyridin-2-ylamine
  参考文献：
  名称：

  PYRIDINE DERIVATIVES SUBSTITUTED BY HETEROCYCLIC RING AND PHOSPHONOAMINO GROUP, AND ANTI-FUNGAL AGENT CONTAINING SAME

  摘要：

  抗真菌剂具有优异的抗真菌作用物理化学性质，包括安全性和水溶性。化合物由式（I）表示，或其盐： 其中R1代表氢，卤素，氨基，R11—NH—其中R11代表C1-6烷基，羟基C1-6烷基，C1-6烷氧基C1-6烷基，或C1-6烷氧羰基C1-6烷基，R12—（CO）—NH—其中R12代表C1-6烷基或C1-6烷氧基C1-6烷基，C1-6烷基，羟基C1-6烷基，氰基C1-6烷基，C1-6烷氧基，或C1-6烷氧基C1-6烷基或磷酰氨基团；R2代表氢，C1-6烷基，氨基，或二C1-6烷基氨基团或磷酰氨基团；X和Y中的一个是氮，另一个是氮或氧；环A代表5-或6-成员杂芳基环或可能具有卤素原子或1或2个C1-6烷基基团的苯环；Z代表单键，亚甲基基团，乙烯基团，氧，硫，—CH2O—，—OCH2—，—NH—，—CH2NH—，—NHCH2—，—CH2S—，或—SCH2—；R3代表氢或卤素或C1-6烷基，C3-8环烷基，C6-10芳基，5-或6-成员杂芳基团或可能具有1或2个取代基的5-或6-成员非芳香杂环基；和R4代表氢或卤素；前提是R1或R2中的一个代表磷酰氨基团。

  公开号：

  US20090082403A1

文献信息

• Heterocycles substituted pyridine derivatives and antifungal agent containing thereof
  申请人：Tanaka Keigo

  公开号：US20070105904A1

  公开（公告）日：2007-05-10

  An object of the present invention is to provide an antifungal agent which has excellent antifungal effects and is superior in terms of its physical properties, safety and metabolic stability. According to the present invention, there is disclosed a compound represented by the following formula (I), or a salt thereof: wherein R 1 represents a hydrogen atom, a halogen atom, an amino group, a C 1-6 alkyl group, a C 1-6 alkoxy group or a C 1-6 alkoxy C 1-6 alkyl group; R 2 represents a hydrogen atom, a C 1-6 alkyl group, an amino group or a di C 1-6 alkylamino group; one of X and Y is a nitrogen atom while the other is a nitrogen atom or an oxygen atom; ring A represents a 5- or 6-member heteroaryl ring or a benzene ring which may have a halogen atom, or 1 or 2 C 1-6 alkyl groups; Z represents a single bond, a methylene group, an ethylene group, an oxygen atom, a sulfur atom, —CH 2 O—, —OCH 2 —, —NH—, —CH 2 NH—, —NHCH 2 —, —CH 2 S—, or —SCH 2 —; R 3 represents a hydrogen atom, a halogen atom, a C 1-6 alkyl group, a C 3-8 cycloalkyl group, a C 6-10 aryl group, a 5- or 6-member heteroaryl group, or 5- or 6-member non-aromatic heterocyclic group which may have 1 or 2 substituents; and R 4 represents a hydrogen atom or a halogen atom.

  本发明的一个目的是提供一种具有优异的抗真菌效果并在其物理性质、安全性和代谢稳定性方面优越的抗真菌剂。根据本发明，公开了以下式(I)所代表的化合物或其盐： 其中R1代表氢原子、卤素原子、氨基、C1-6烷基、C1-6烷氧基或C1-6烷氧基C1-6烷基；R2代表氢原子、C1-6烷基、氨基或二C1-6烷基氨基中的一个；X和Y中的一个是氮原子，另一个是氮原子或氧原子；环A代表一个5-或6-成员杂芳基环或可能具有卤素原子、1个或2个C1-6烷基的苯环；Z代表一个单键、一个亚甲基基、一个乙烯基、一个氧原子、一个硫原子、-CH2O-、-OCH2-、-NH-、-CH2NH-、-NHCH2-、-CH2S-或-SCH2-；R3代表氢原子、卤素原子、C1-6烷基、C3-8环烷基、C6-10芳基、一个5-或6-成员杂芳基、或可能具有1个或2个取代基的5-或6-成员非芳香杂环基；R4代表氢原子或卤素原子。
• HETEROCYCLES SUBSTITUTED PYRIDINE DERIVATIVES AND ANTIFUNGAL AGENT CONTAINING THEREOF
  申请人：TANAKA Keigo

  公开号：US20120029023A1

  公开（公告）日：2012-02-02

  An object of the present invention is to provide an antifungal agent which has excellent antifungal effects and is superior in terms of its physical properties, safety and metabolic stability. According to the present invention, there is disclosed a compound represented by the following formula (I), or a salt thereof: wherein R 1 , R 2 , X, Y, ring A, Z, R 3 and R 4 are as defined in the specification.

  本发明的目的是提供一种具有优异的抗真菌效果且在物理性质、安全性和代谢稳定性方面优越的抗真菌剂。根据本发明，公开了下式（I）所表示的化合物或其盐：其中R1、R2、X、Y、环A、Z、R3和R4如规范中所定义。
• AGRICULTURAL COMPOSITION
  申请人：Matsuzaki Yuichi

  公开号：US20110201649A1

  公开（公告）日：2011-08-18

  Provided is an agricultural composition comprising a compound represented by the formula (I) or a salt thereof or a hydrate thereof, for controlling a plant disease due to a plant pathogen: [wherein, G represents a di-valent aromatic hetero 5-membered ring optionally having a halogen atom or C1 to 3 alkyl group (with the proviso that a hetero atom of the aromatic hetero 5-membered ring is a nitrogen atom, oxygen atom or sulfur atom), R 1 represents a hydrogen atom or amino group, R 2 , R 3 and R 4 represent each independently a hydrogen atom or the like, and E represents an optionally substituted 5 to 10-membered heterocyclic group or C6-10 aryl group.].

  提供的是一种农业组合物，包括由式(I)或其盐或水合物表示的化合物，用于控制由植物病原体引起的植物病害：[其中，G代表一个二价芳香杂环五元环，可选地具有卤原子或C1至3烷基（前提是芳香杂环五元环的杂原子是氮原子、氧原子或硫原子），R1代表氢原子或氨基，R2、R3和R4分别独立地代表氢原子或类似物，E代表可选地取代的5到10元杂环基或C6-10芳基。]。
• PYRIDINE DERIVATIVE SUBSTITUTED BY HETEROCYCLE AND FUNGICIDE CONTAINING THE SAME
  申请人：Eisai R&D Management Co., Ltd.

  公开号：EP1944303A1

  公开（公告）日：2008-07-16

  An object of the present invention is to provide an antifungal agent which has excellent antifungal effects and is superior in terms of its physical properties, safety and metabolic stability. According to the present invention, there is disclosed a compound represented by the following formula (I), or a salt thereof: wherein R1 represents a hydrogen atom, a halogen atom, an amino group, a C1-6 alkyl group, a C1-6 alkoxy group or a C1-6 alkoxy C1-6 alkyl group; R2 represents a hydrogen atom, a C1-6 alkyl group, an amino group or a di C1-6 alkylamino group; one of X and Y is a nitrogen atom while the other is a nitrogen atom or an oxygen atom; ring A represents a 5- or 6-member heteroaryl ring or a benzene ring which may have a halogen atom, or 1 or 2 C1-6 alkyl groups; Z represents a single bond, a methylene group, an ethylene group, an oxygen atom, a sulfur atom, -CH2O-, -OCH2-, -NH-, - CH2NH-, -NHCH2-, -CH2S-, or -SCH2-; R3 represents a hydrogen atom, a halogen atom, a C1-6 alkyl group, a C3-8 cycloalkyl group, a C6-10 aryl group, a 5- or 6-member heteroaryl group, or 5- or 6-member non-aromatic heterocyclic group which may have 1 or 2 substituents; and R4 represents a hydrogen atom or a halogen atom.

  本发明的目的是提供一种抗真菌剂，该抗真菌剂具有优异的抗真菌效果，并且在物理性质、安全性和新陈代谢稳定性方面更胜一筹。根据本发明，公开了由下式（I）代表的化合物或其盐： 其中 R1 代表氢原子、卤素原子、氨基、C1-6 烷基、C1-6 烷氧基或 C1-6 烷氧基 C1-6 烷基；R2 代表氢原子、C1-6 烷基、氨基或二 C1-6 烷基氨基；X 和 Y 中的一个为氮原子，另一个为氮原子或氧原子；环 A 代表 5 或 6 元杂芳基环或苯环，该环可带有卤素原子或 1 或 2 个 C1-6 烷基；Z 代表单键、亚甲基、亚乙基、氧原子、硫原子、-CH2O-、-OCH2-、-NH-、-CH2NH-、-NHCH2-、-CH2S- 或 -SCH2-；R3 代表氢原子、卤素原子、C1-6 烷基、C3-8 环烷基、C6-10 芳基、5 或 6 元杂芳基或 5 或 6 元非芳香杂环基，它们可以有 1 或 2 个取代基；以及 R4 代表氢原子或卤素原子。
• PYRIDINE DERIVATIVE SUBSTITUTED WITH HETEROCYCLE AND PHOSPHONOAMINO AND ANTIFUNGAL AGENT CONTAINING THE SAME
  申请人：Eisai R&D Management Co., Ltd.

  公开号：EP2141171A1

  公开（公告）日：2010-01-06

  The present invention provides an anti-fungal agent having an excellent anti-fungal action and excellent physicochemical properties such as safety and solubility in water. The present invention discloses a compound represented by the following formula (I) or a salt thereof: [wherein R1 represents a hydrogen atom, a halogen atom, an amino group, R11-NH-(wherein R11 represents a C1-6 alkyl group, a hydroxy C1-6 alkyl group, a C1-6 alkoxy C1-6 alkyl group or a C1-6alkoxycarbonyl C1-6 alkyl group), R12-(CO)-NH- (wherein R12 represents a C1-6 alkyl group or a C1-6 alkoxy C1-6 alkyl group), a C1-6 alkyl group, a hydroxy C1-6 alkyl group, a cyano C1-6 alkyl group, a C1-6 alkoxy group or a C1-6 alkoxy C1-6 alkyl group or a phosphonoamino group; R2 represents a hydrogen atom, a C1-6 alkyl group, an amino group or a di C1-6 alkylamino group or a phosphonoamino group; one of X and Y is a nitrogen atom while the other is a nitrogen atom or an oxygen atom; ring A represents a 5- or 6-member heteroaryl ring or a benzene ring which may have a halogen atom or 1 or 2 C1-6 alkyl groups; Z represents a single bond, a methylene group, an ethylene group, an oxygen atom, a sulfur atom, -CH2O-, -OCH2-, -NH-, -CH2NH-, -NHCH2-, -CH2S- or -SCH2-; R3 represents a hydrogen atom or a halogen atom or a C1-6 alkyl group, a C3-8 cycloalkyl group, a C6-10 aryl group, a 5- or 6-member heteroaryl group or a 5- or 6-member nonaromatic heterocyclic group which may have 1 or 2 substituents; and R4 represents a hydrogen atom or halogen atom; provided that either R1 or R2 represents a phosphonoamino group.]

  本发明提供了一种抗真菌剂，它具有优异的抗真菌作用和优良的理化性质，如安全性和水溶性。本发明公开了由下式（I）代表的化合物或其盐： [其中 R1 代表氢原子、卤素原子、氨基、R11-NH-（其中 R11 代表 C1-6 烷基、羟基 C1-6 烷基、C1-6 烷氧基 C1-6 烷基或 C1-6 烷氧基羰基 C1-6 烷基）、R12-(CO)-NH-（其中 R12 代表 C1-6 烷基或 C1-6 烷氧基 C1-6 烷基）、C1-6 烷基、羟基 C1-6 烷基、氰基 C1-6 烷基、C1-6 烷氧基或 C1-6 烷氧基 C1-6 烷基或磷酰氨基；R2 代表氢原子、C1-6 烷基、氨基或二 C1-6 烷基氨基或磷酰氨基；X 和 Y 中的一个是氮原子，另一个是氮原子或氧原子；环 A 代表 5 或 6 个成员的杂芳基环或苯环，其中可能有卤素原子或 1 或 2 个 C1-6 烷基；Z 代表单键、亚甲基、亚乙基、氧原子、硫原子、-CH2O-、-OCH2-、-NH-、-CH2NH-、-NHCH2-、-CH2S- 或-SCH2-；R3 代表氢原子或卤素原子或 C1-6 烷基、C3-8 环烷基、C6-10 芳基、5 或 6 个成员的杂芳基或 5 或 6 个成员的非芳香杂环基团，这些基团可以有 1 或 2 个取代基；以及 R4 代表氢原子或卤素原子；前提是 R1 或 R2 代表膦酰氨基。]