1-benzyloxy-4-fluoro-4-phenylsulfonyl-octane-3-ol | 911434-39-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-benzyloxy-4-fluoro-4-phenylsulfonyl-octane-3-ol
• 英文别名: 4-(Benzenesulfonyl)-4-fluoro-1-phenylmethoxyoctan-3-ol；4-(benzenesulfonyl)-4-fluoro-1-phenylmethoxyoctan-3-ol
• CAS: 911434-39-4
• 化学式: C₂₁H₂₇FO₄S
• 分子量: 394.507
• InChiKey: HRJAJUXSLWZMGG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  27
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  72
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  1-benzyloxy-4-fluoro-4-phenylsulfonyl-octane-3-ol 、 苯甲酰氯 以 吡啶 为溶剂， 以54%的产率得到3-benzoyloxy-1-benzyloxy-4-fluoro-4-phenylsulfonyloctane
  参考文献：
  名称：

  Synthesis and biological evaluation of γ-fluoro-β,γ-unsaturated acids

  摘要：

  Several gamma-fluoro-beta, gamma-unsaturated acids, fluorine-containing analogues of N-acyl glycines, were synthesized via Julia-Lythgoe olefination. The antimicrobial activities of these compounds and synthetic intermediates were evaluated. Analogues with an octyl group showed in vitro antifungal activity agaist Penicillium chrysogenum IFO4626. (c) 2006 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jfluchem.2006.02.016
• 作为产物：
  描述：

  1-fluoro-1-phenylsulfonylpentane 、 3-苄氧基丙醛 在 正丁基锂 作用下， 以 乙二醇二甲醚 、 正己烷 为溶剂， 反应 0.5h， 以70%的产率得到1-benzyloxy-4-fluoro-4-phenylsulfonyl-octane-3-ol
  参考文献：
  名称：

  Synthesis and biological evaluation of γ-fluoro-β,γ-unsaturated acids

  摘要：

  Several gamma-fluoro-beta, gamma-unsaturated acids, fluorine-containing analogues of N-acyl glycines, were synthesized via Julia-Lythgoe olefination. The antimicrobial activities of these compounds and synthetic intermediates were evaluated. Analogues with an octyl group showed in vitro antifungal activity agaist Penicillium chrysogenum IFO4626. (c) 2006 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jfluchem.2006.02.016

文献信息

• Synthesis and biological evaluation of γ-fluoro-β,γ-unsaturated acids
  作者：Noriaki Asakura、Yoshinosuke Usuki、Hideo Iio、Toshio Tanaka

  DOI：10.1016/j.jfluchem.2006.02.016

  日期：2006.6

  Several gamma-fluoro-beta, gamma-unsaturated acids, fluorine-containing analogues of N-acyl glycines, were synthesized via Julia-Lythgoe olefination. The antimicrobial activities of these compounds and synthetic intermediates were evaluated. Analogues with an octyl group showed in vitro antifungal activity agaist Penicillium chrysogenum IFO4626. (c) 2006 Elsevier B.V. All rights reserved.