2-methyl-3-(2-thienyl)acrylic acid | 40527-55-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 杂芳族化合物
• 英文名称: 2-methyl-3-(2-thienyl)acrylic acid
• 英文别名: α-Methyl-β-thienylacrylsaeure；2-methyl-3-thiophen-2-yl-acrylic acid；2-methyl-3ξ-[2]thienyl-acrylic acid；2-Methyl-3ξ-[2]thienyl-acrylsaeure；2-Methyl-3-thiophen-2-ylprop-2-enoic acid
• CAS: 40527-55-7
• 化学式: C₈H₈O₂S
• 分子量: 168.216
• InChiKey: MOHSXXGDTJEXNH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  65.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-methyl-3-(2-thienyl)acrylic acid 在 氯化亚砜 作用下， 以 苯 为溶剂， 反应 3.0h， 生成 α-Methyl-β-thienylacryloylchlorid
  参考文献：
  名称：

  Pyrimidine derivatives. 4. Synthesis and antihypertensive activity of 4-amino-2-(4-cinnamoylpiperazino)-6,7-dimethoxyquinazoline derivatives

  摘要：

  A series of 30 4-amino-2-(4-cinnamoylpiperazino)-6,7-dimethoxyquinazoline derivatives was prepared and tested for their ability to reduce blood pressure in conscious, spontaneously hypertensive rates (SHR). A number of these compounds, notably 4-amino-2-(4-cinnamoylpiperazino)-6,7-dimethoxyquinazolines 3a (R1 = H; R2 = Ph), 3j (R1 = H; R2 = 4-EtOPh), and 5a (R1 = H; R2 = 2-furyl), showed activity at oral doses of 0.3-10 mg/kg. The effects of the 4-substituents of the piperazino group on activity are discussed. Compounds 3a, 3j, and 5a were effective in renal hypertensive rats at oral doses of 3 and 10 mg/kg and showed alpha-adrenoceptor blocking effects in isolated aortas of rats. A 5-day consecutive oral administration of 3a and 3j in SHR did not lead to development of tolerance.

  DOI：

  10.1021/jm00357a016
• 作为产物：
  描述：

  3-hydroxy-2-methyl-3-[2]thienyl-propionic acid ethyl ester 在 氢氧化钾 作用下， 生成 2-methyl-3-(2-thienyl)acrylic acid
  参考文献：
  名称：

  STUDIES IN THE THIOPHENE SERIES. VII.¹ THE APPLICATION OF THE REFORMATSKY REACTION TO THIOPHENE ALDEHYDES AND KETONES

  摘要：

  DOI：

  10.1021/jo01147a015

文献信息

• Fused imidazo[1,2-A]pyridines
  申请人：Shinnippon Pharmaceutical, Inc.

  公开号：US06020342A1

  公开（公告）日：2000-02-01

  Compounds of the formula: ##STR1## which are useful as anti-ulcer agent are provided.

  提供了化学式为##STR1##的化合物，这些化合物可用作抗溃疡剂。
• Fused imidazo[1,2-a]pyridines
  申请人：Shinnippon Pharmaceutical Inc.

  公开号：US06103736A1

  公开（公告）日：2000-08-15

  Compounds of the formula: ##STR1## which are useful as anti-ulcer agent are provided.

  提供了化学式为##STR1##的化合物，它们可用作抗溃疡剂。
• Xcxnhxc-nh
  申请人：——

  公开号：US02734904A1

  公开（公告）日：1956-02-14

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