methyl 4-chloro-7-methyl-1,8-naphthyridine-3-carboxylate | 128056-40-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: methyl 4-chloro-7-methyl-1,8-naphthyridine-3-carboxylate
• CAS: 128056-40-6
• 化学式: C₁₁H₉ClN₂O₂
• 分子量: 236.658
• InChiKey: JBILJIWEDOCXMI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  52.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  methyl 4-chloro-7-methyl-1,8-naphthyridine-3-carboxylate 、 4-氯苯肼 以 xylene 为溶剂， 反应 8.0h， 以64%的产率得到2-(4-chlorophenyl)-7-methyl-3H-pyrazolo<4,3-c>-1,8-naphthyridin-3-one
  参考文献：
  名称：

  Synthesis and evaluation of a series of aryl[e]fused pyrazolo[4,3-c]pyridines with potential anxiolytic activity

  摘要：

  A series of pyrazolo[4,3-c]pyridines has been synthesized and evaluated as potential anxiolytic agents. Selected compounds from this series show a pharmacological profile of action different from that of diazepam. A number of the compounds possess higher affinity for central benzodiazepine receptors than diazepam, yet show less anticonvulsant activity and are less sedative. The structure-activity relationships of these potential anxiolytic agents are discussed.

  DOI：

  10.1021/jm00171a046
• 作为产物：
  描述：

  N-<6-Methyl-<2>pyridyl>-aminomethylenmalonsaeure-dimethylester 在 三氯氧磷 作用下， 生成 methyl 4-chloro-7-methyl-1,8-naphthyridine-3-carboxylate
  参考文献：
  名称：

  Synthesis and evaluation of a series of aryl[e]fused pyrazolo[4,3-c]pyridines with potential anxiolytic activity

  摘要：

  A series of pyrazolo[4,3-c]pyridines has been synthesized and evaluated as potential anxiolytic agents. Selected compounds from this series show a pharmacological profile of action different from that of diazepam. A number of the compounds possess higher affinity for central benzodiazepine receptors than diazepam, yet show less anticonvulsant activity and are less sedative. The structure-activity relationships of these potential anxiolytic agents are discussed.

  DOI：

  10.1021/jm00171a046

文献信息

• Heber; Verborg; Mohr, Arzneimittel-Forschung/Drug Research, 1994, vol. 44, # 7, p. 809 - 814
  作者：Heber、Verborg、Mohr

  DOI：——

  日期：——
• FORBES, IAN T.;JOHNSON, CHRISTOPHER N.;JONES, GRAHAM E.;LOUDON, JULIA;NIC+, J. MED. CHEM., 33,(1990) N, C. 2640-2645
  作者：FORBES, IAN T.、JOHNSON, CHRISTOPHER N.、JONES, GRAHAM E.、LOUDON, JULIA、NIC+

  DOI：——

  日期：——
• Synthesis and evaluation of a series of aryl[e]fused pyrazolo[4,3-c]pyridines with potential anxiolytic activity
  作者：Ian T. Forbes、Christopher N. Johnson、Graham E. Jones、Julia Loudon、Jane M. Nicholass、Mervyn Thompson、Neil Upton

  DOI：10.1021/jm00171a046

  日期：1990.9

  A series of pyrazolo[4,3-c]pyridines has been synthesized and evaluated as potential anxiolytic agents. Selected compounds from this series show a pharmacological profile of action different from that of diazepam. A number of the compounds possess higher affinity for central benzodiazepine receptors than diazepam, yet show less anticonvulsant activity and are less sedative. The structure-activity relationships of these potential anxiolytic agents are discussed.