2-(3-methoxy-5H-dibenz[c,e]azepin-5-yl)acrylonitrile | 1611486-29-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯氮卓类
• 英文名称: 2-(3-methoxy-5H-dibenz[c,e]azepin-5-yl)acrylonitrile
• 英文别名: 2-(3-methoxy-5H-benzo[d][2]benzazepin-5-yl)prop-2-enenitrile
• CAS: 1611486-29-3
• 化学式: C₁₈H₁₄N₂O
• 分子量: 274.322
• InChiKey: YEKNKAWQVBOALZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  45.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  N-[2-cyano-1-(2'-formyl-4-methoxybiphenyl-2-yl)allyl]benzamide 在 盐酸 作用下， 以 乙醇 、 水 为溶剂， 反应 2.0h， 以92%的产率得到2-(3-methoxy-5H-dibenz[c,e]azepin-5-yl)acrylonitrile
  参考文献：
  名称：

  An alternate route to substituted 6,7-dihydro 5H-dibenz[c,e]azepines from allylbenzamides derived from the Morita–Baylis–Hillman adducts

  摘要：

  An acid-catalyzed modular synthesis of substituted 5H-dibenz[c,e]azepines from a biaryl allylbenzamides prepared from the MBH adducts via a cascade dearoylation and intramolecular cyclization is described. The utility of the product for preparing 7,9-dihydro-4bH-dibenz[c,e]pyrrolo[1,2-alpha]azepine is also presented. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2014.04.055

文献信息

• An alternate route to substituted 6,7-dihydro 5H-dibenz[c,e]azepines from allylbenzamides derived from the Morita–Baylis–Hillman adducts
  作者：Subhendu Bhowmik、Soumya Bhattacharyya、Sanjay Batra

  DOI：10.1016/j.tet.2014.04.055

  日期：2014.7

  An acid-catalyzed modular synthesis of substituted 5H-dibenz[c,e]azepines from a biaryl allylbenzamides prepared from the MBH adducts via a cascade dearoylation and intramolecular cyclization is described. The utility of the product for preparing 7,9-dihydro-4bH-dibenz[c,e]pyrrolo[1,2-alpha]azepine is also presented. (C) 2014 Elsevier Ltd. All rights reserved.