Benzyl-(1-isopropyl-2-methyl-propylidene)-amine | 132067-23-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Benzyl-(1-isopropyl-2-methyl-propylidene)-amine
• 英文别名: N-benzyl-2,4-dimethylpentan-3-imine
• CAS: 132067-23-3
• 化学式: C₁₄H₂₁N
• 分子量: 203.327
• InChiKey: VUKRGPIQBGYAIG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  12.4
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  CBZ-L-缬氨酸 、 异腈基乙酸甲酯 、 Benzyl-(1-isopropyl-2-methyl-propylidene)-amine 以 二氯甲烷 为溶剂， 反应 336.0h， 以61%的产率得到{2-[Benzyl-((S)-2-benzyloxycarbonylamino-3-methyl-butyryl)-amino]-2-isopropyl-3-methyl-butyrylamino}-acetic acid methyl ester
  参考文献：
  名称：

  高压下的四组分缩合（Ugi反应）：含有非常庞大的α，α-二取代甘氨酸的肽的新型合成

  摘要：

  含有非常庞大的α，α-二取代甘氨酸（例如N-苄基-α，α-二异丙基甘氨酸或N-苄基-α，α-二苯基甘氨酸）的肽Z-Val-X-Gly-OMe，其残基X可以在高压（9 kbar，0.9 GPa）下通过四组分缩合（Ugi反应）以中等收率合成。

  DOI：

  10.1039/c39900001640

文献信息

• Polyene polyketides, processes for their production and their use as a pharmaceutical
  申请人：Zazopoulos Emmanuel

  公开号：US20070275436A1

  公开（公告）日：2007-11-29

  This invention relates to a new class of polyene polyketides, their pharmaceutically acceptable salts and derivatives, and to methods for obtaining the compounds. One method of obtaining these compounds is by cultivation of novel strains of Streptomyces aizunensis ; another method involves expression of biosynthetic pathway genes in transformed host cells. The present invention further relates to the novel strains of Streptomyces aizunensis used to produce these compounds, to the use of these compounds and their pharmaceutically acceptable salts and derivatives as pharmaceuticals, in particular to their use as inhibitors of fungal cell growth and cancer cell growth. The invention also relates to pharmaceutical compositions comprising these novel polyketides or a pharmaceutically acceptable salts or derivatives thereof. Finally, the invention relates to novel polynucleotide sequences and their encoded proteins, which are involved in the biosynthesis of these novel polyketides.
• US7375088B2
  申请人：——

  公开号：US7375088B2

  公开（公告）日：2008-05-20
• US7416868B2
  申请人：——

  公开号：US7416868B2

  公开（公告）日：2008-08-26
• Four-component condensation (Ugi reaction) at high pressure: novel synthesis of peptides containing very bulky α,α-disubstituted glycines
  作者：Takashi Yamada、Takashi Yanagi、Yuichiro Omote、Toshifumi Miyazawa、Shigeru Kuwata、Makiko Sugiura、Kiyoshi Matsumoto

  DOI：10.1039/c39900001640

  日期：——

  Peptides, Z-Val-X-Gly-OMe, containing a very bulky α,α-disubstituted glycine, such as N-benzyl-α,α-diisopropylglycine or N-benzyl-α,α-diphenylglycine, as the residue X can be synthesized in moderate yields by four-component condensation (Ugi reaction) at high pressure (9 kbar, 0.9 GPa).

  含有非常庞大的α，α-二取代甘氨酸（例如N-苄基-α，α-二异丙基甘氨酸或N-苄基-α，α-二苯基甘氨酸）的肽Z-Val-X-Gly-OMe，其残基X可以在高压（9 kbar，0.9 GPa）下通过四组分缩合（Ugi反应）以中等收率合成。