1-(4-chloro-benzenesulfonyl)-2-methyl-piperidine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(4-chloro-benzenesulfonyl)-2-methyl-piperidine
• 英文别名: 1-(4-Chlorobenzenesulfonyl)-2-methylpiperidine；1-(4-chlorophenyl)sulfonyl-2-methylpiperidine
• 化学式: C₁₂H₁₆ClNO₂S
• 分子量: 273.784
• InChiKey: MEPGZXMSAHELSU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  45.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-氯苯磺酰氯 、 2-甲基哌啶 在 吡啶 作用下， 生成 1-(4-chloro-benzenesulfonyl)-2-methyl-piperidine
  参考文献：
  名称：

  Discovery of a novel sulfonamide-pyrazolopiperidine series as potent and Efficacious γ-Secretase Inhibitors

  摘要：

  Discovery of a series of pyrazolopiperidine sulfonamide based gamma-secretase inhibitors and its SAR evolution is described. Significant increases in APP potency on the pyrazolopiperidine scaffold over the original N-bicyclic sulfonamide scaffold were achieved and this potency increase translated in an improved in vivo efficacy. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.02.039

文献信息

• Heterocyclic Compounds Which Modulate The CB2 Receptor
  申请人：Bartolozzi Alessandra

  公开号：US20110312944A1

  公开（公告）日：2011-12-22

  Compounds which modulate the CB2 receptor are disclosed. Compounds according to the invention bind to and are agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.

  本发明揭示了调节CB2受体的化合物。根据本发明，这些化合物与CB2受体结合并作为激动剂，用于治疗炎症。那些作为激动剂的化合物还可用于治疗疼痛。
• Bridged N-Cyclic Sulfonamido Inhibitors of Gamma Secretase
  申请人：Bowers Simeon

  公开号：US20110003802A1

  公开（公告）日：2011-01-06

  The invention provides N-cyclic sulfonamido compounds and salts of Formula I: wherein A is as described in the specification and R 1 and R 2 combine to form a [3.3.1] or a [3.2.1] ring system, where the nitrogen is attached to the two bridgehead carbons, and the [3.3.1] or [3.2.1] ring systems are optionally fused with an heteroaryl or heterocycloalkyl ring. Compounds of Formula I are useful in treating or preventing cognitive disorders, such as Alzheimer's Disease. The invention also encompasses pharmaceutical compositions comprising compounds of Formula I, methods of treating cognitive disorders, such as Alzheimer's disease, and the intermediates useful in preparing the compounds of Formula I.

  本发明提供了式I的N-环磺酰胺化合物和盐，其中A如说明书所述，且R1和R2结合形成[3.3.1]或[3.2.1]环系统，其中氮原子连接到两个桥头碳原子，并且[3.3.1]或[3.2.1]环系统可以与杂环芳烃或杂环烷基环融合。I式化合物在治疗或预防认知障碍，如阿尔茨海默病方面有用。本发明还包括包含I式化合物的制药组合物，治疗认知障碍，如阿尔茨海默病的方法，以及制备I式化合物的中间体。
• N-cyclic sulfonamido inhibitors of gamma secretase
  申请人：Neitzel L. Martin

  公开号：US20060035884A1

  公开（公告）日：2006-02-16

  The invention provides N-cyclic sulfonamido compounds for use in treating or preventing cognitive disorders, such as Alzheimer's Disease. Compounds of particular interest are defined by Formula I, wherein R 4 , R 5 , R 6 , R 7 , and R 8 , are as described in the specification. The invention also encompasses pharmaceutical compositions comprising compounds of Formula I as well as methods of treating cognitive disorders, including Alzheimer's disease using compounds of Formula I.

  本发明提供了用于治疗或预防认知障碍（如阿尔茨海默病）的 N-环磺酰胺基化合物。 特别感兴趣的化合物由式 I 定义，其中 R 4 , R 5 , R 6 , R 7 和 R 8 如说明书所述。本发明还包括由式 I 化合物组成的药物组合物，以及使用式 I 化合物治疗认知障碍（包括阿尔茨海默病）的方法。
• N-CYCLIC SULFONAMIDO INHIBITORS OF GAMMA SECRETASE
  申请人：ELAN PHARMACEUTICALS, INC.

  公开号：EP1758884A2

  公开（公告）日：2007-03-07
• US8889670B2
  申请人：——

  公开号：US8889670B2

  公开（公告）日：2014-11-18