Octyl-(1-p-tolyl-ethyl)-amine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Octyl-(1-p-tolyl-ethyl)-amine
• 英文别名: [1-(4-Methylphenyl)ethyl](octyl)amine；N-[1-(4-methylphenyl)ethyl]octan-1-amine
• 化学式: C₁₇H₂₉N
• mdl: MFCD00965203
• 分子量: 247.424
• InChiKey: ABGMVYNODOXUIR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  18
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.647
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  甲基碘化镁 、 N-(4-methylbenzylidene)octan-1-amine 在 1-(三甲基硅基)苯并三氮唑 作用下， 以 乙醚 、 甲苯 为溶剂， 反应 20.0h， 以72%的产率得到Octyl-(1-p-tolyl-ethyl)-amine
  参考文献：
  名称：

  Preparations of Secondary Amines and .beta.-Amino Esters via Additions of Grignard and Reformatsky Reagents to Imines and by One-Pot Reactions of Primary Amines, Aldehydes, and Grignards

  摘要：

  Additions oi. Grignard and Reformatsky reagents to imines in the presence of 1-(trimethylsilyl)benzotriazole afforded in good yields the corresponding secondary amines and p-amino esters. The procedure is general as imines containing hydrogens a to both carbon and nitrogen can be employed. Extensions of this method to include imines containing other Lewis basic centers, e.g., those derived from furan-, thiophene-, indole-, and p-methoxybenzenecarboxaldehyde, have been successful in avoiding the potential complications which could result from the use of a Lewis acid as the activating : species. The imines need not be isolated, and a one-pot method for the synthesis of secondary amines from aldehydes, primary amines, and Grignard reagents is described.

  DOI：

  10.1021/jo00116a027

文献信息

• 1-(Trimethylsilyl)benzotriazole-Assisted Addition of Grignard Reagents to Imines: A Versatile Approach to Aliphatic Secondary Amines
  作者：Alan R. Katritzky、Qingmei Hong、Zhijun Yang

  DOI：10.1021/jo00105a003

  日期：1994.12

  1-(Trimethylsilyl)benzotriazole-assisted Grignard addition to imines is described.
• Preparations of Secondary Amines and .beta.-Amino Esters via Additions of Grignard and Reformatsky Reagents to Imines and by One-Pot Reactions of Primary Amines, Aldehydes, and Grignards
  作者：Alan R. Katritzky、Qingmei Hong、Zhijun Yang

  DOI：10.1021/jo00116a027

  日期：1995.6

  Additions oi. Grignard and Reformatsky reagents to imines in the presence of 1-(trimethylsilyl)benzotriazole afforded in good yields the corresponding secondary amines and p-amino esters. The procedure is general as imines containing hydrogens a to both carbon and nitrogen can be employed. Extensions of this method to include imines containing other Lewis basic centers, e.g., those derived from furan-, thiophene-, indole-, and p-methoxybenzenecarboxaldehyde, have been successful in avoiding the potential complications which could result from the use of a Lewis acid as the activating : species. The imines need not be isolated, and a one-pot method for the synthesis of secondary amines from aldehydes, primary amines, and Grignard reagents is described.