(3-chloro-4,4-difluorohex-5-enyl)benzene | 1400566-47-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (3-chloro-4,4-difluorohex-5-enyl)benzene
• 英文别名: (3-Chloro-4,4-difluorohex-5-enyl)benzene
• CAS: 1400566-47-3
• 化学式: C₁₂H₁₃ClF₂
• 分子量: 230.685
• InChiKey: SBDNCZQSAWJPJF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4,4-difluoro-1-phenylhex-5-en-3-ol 在 4-二甲氨基吡啶 、 lithium chloride 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 40.0h， 生成 (3-chloro-4,4-difluorohex-5-enyl)benzene
  参考文献：
  名称：

  Regio- and Diastereoselective Nickel-Catalyzed Allylation of Aromatic Aldehydes with α-Halo-β,β-difluoropropene Derivatives

  摘要：

  A one-pot nickel-catalyzed allylation of aromatic aldehydes with alpha-halo-beta,beta-difluoropropene-containing compounds promoted by ZnEt2 under mild conditions was described. The reaction displays moderate to good regio- and diastereoselectivity, tolerates a wide range of functional groups, and provides an efficient method for the synthesis of gamma-fluorinated homoallylic alcohols.

  DOI：

  10.1021/jo301688d

文献信息

• Regio- and Diastereoselective Nickel-Catalyzed Allylation of Aromatic Aldehydes with α-Halo-β,β-difluoropropene Derivatives
  作者：Xiaowei Lin、Feng Zheng、Feng-Ling Qing

  DOI：10.1021/jo301688d

  日期：2012.10.5

  A one-pot nickel-catalyzed allylation of aromatic aldehydes with alpha-halo-beta,beta-difluoropropene-containing compounds promoted by ZnEt2 under mild conditions was described. The reaction displays moderate to good regio- and diastereoselectivity, tolerates a wide range of functional groups, and provides an efficient method for the synthesis of gamma-fluorinated homoallylic alcohols.