[4-(Naphthalene-1-sulfonyl)-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl]-acetic acid | 212578-52-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: [4-(Naphthalene-1-sulfonyl)-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl]-acetic acid
• 英文别名: 2-(4-Naphthalen-1-ylsulfonyl-2,3-dihydro-1,4-benzoxazin-2-yl)acetic acid
• CAS: 212578-52-4
• 化学式: C₂₀H₁₇NO₅S
• 分子量: 383.425
• InChiKey: HPMIXPQVJOSLKK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  92.3
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  [4-(Naphthalene-1-sulfonyl)-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl]-acetic acid 在 dimethyl sulfide borane 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 9.0h， 生成 [2-(3,4-Dimethoxy-phenyl)-ethyl]-{2-[4-(naphthalene-1-sulfonyl)-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl]-ethyl}-amine
  参考文献：
  名称：

  New Substituted 1,4-Benzoxazine Derivatives with Potential Intracellular Calcium Activity

  摘要：

  Substituted 1,4-benzoxazines bearing an amino side chain at the 2-position were prepared and were found to have a moderate activity on intracellular calcium. Of the compounds studied it was found that those which possess a homoveratrylamino moiety exhibited superior potency. The chain length and the nature of the amine (4-fluorophenylpiperazine, 4-fluorobenzhydryloxyethylamine, N-substituted homoveratrylamine) is discussed. The 4-benzyl-3,4-dihydro-2[3-[[2-(3,4-dimethoxyphenyl)ethyl]amino]propyl]-2H-1,4-benzoxazine (3c) is the most potent derivative of the series with a ratio of IC50 values against PE (phenylephrine) and K+ of 2.1. Under these test conditions a ratio near 1 indicates potential intracellular calcium activity while a ratio greater than 100 an action on extracellular calcium influx.

  DOI：

  10.1021/jm970795t
• 作为产物：
  描述：

  2-(苯基亚甲基氨基)苯酚 在 palladium on activated charcoal 氢氧化钾 、 sodium tetrahydroborate 、 氢气 、 碳酸氢钠 、 potassium carbonate 、 三乙胺 作用下， 以 乙醇 、 溶剂黄146 、 甲苯 为溶剂， 反应 21.0h， 生成 [4-(Naphthalene-1-sulfonyl)-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl]-acetic acid
  参考文献：
  名称：

  New Substituted 1,4-Benzoxazine Derivatives with Potential Intracellular Calcium Activity

  摘要：

  Substituted 1,4-benzoxazines bearing an amino side chain at the 2-position were prepared and were found to have a moderate activity on intracellular calcium. Of the compounds studied it was found that those which possess a homoveratrylamino moiety exhibited superior potency. The chain length and the nature of the amine (4-fluorophenylpiperazine, 4-fluorobenzhydryloxyethylamine, N-substituted homoveratrylamine) is discussed. The 4-benzyl-3,4-dihydro-2[3-[[2-(3,4-dimethoxyphenyl)ethyl]amino]propyl]-2H-1,4-benzoxazine (3c) is the most potent derivative of the series with a ratio of IC50 values against PE (phenylephrine) and K+ of 2.1. Under these test conditions a ratio near 1 indicates potential intracellular calcium activity while a ratio greater than 100 an action on extracellular calcium influx.

  DOI：

  10.1021/jm970795t