苯酰胺,N-[(4-硝基苯甲酰)氧代]- | 1037-48-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 苯酰胺,N-[(4-硝基苯甲酰)氧代]-
• 英文名称: O-p-nitrobenzoylbenzohydroxamic acid
• 英文别名: N-benzoyl-O-(4-nitro-benzoyl)-hydroxylamine；N-Benzoyl-O-(4-nitro-benzoyl)-hydroxylamin；Benzhydroxamsaeure-(4-nitro-benzoat)；N-Benzoyl-O-<4-nitro-benzoyl>-hydroxylamin；N-Benzoyl-O-(4-nitro-benzoyl)-hydroxylamin；N-Benzoyl-O-p-nitrobenzoylhydroxylamin；N-[(4-Nitrobenzoyl)oxy]benzamide；benzamido 4-nitrobenzoate
• CAS: 1037-48-5
• 化学式: C₁₄H₁₀N₂O₅
• 分子量: 286.244
• InChiKey: AJLZPQVYTYGECX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  101
• 氢给体数：
  1
• 氢受体数：
  5

安全信息

• 海关编码：
  2924299090

反应信息

• 作为反应物：
  描述：

  苯酰胺,N-[(4-硝基苯甲酰)氧代]- 在 三氯异氰尿酸 作用下， 以 二氯甲烷 为溶剂， 生成 N-chloro-N-(4-nitrobenzoyloxy)-benzamide
  参考文献：
  名称：

  Optimization of HNO Production from N,O-bis-Acylated Hydroxylamine Derivatives

  摘要：

  A wide range of N,O-bis-acylated hydroxylamine derivatives with chloro or arenesulfonyl leaving groups, and a related set of N-hydroxy-N-acylsulfonamides, have been synthesized and evaluated for nitroxyl (HNO) production. Mechanistic studies have revealed that the observed aqueous chemistry is more complicated than originally anticipated, and have been used to develop a new series of efficient HNO precursors (4u-4x, 7c-7d) with tunable half-lives.

  DOI：

  10.1021/ol203016c
• 作为产物：
  描述：

  硝基甲苯 在 乙醚 、 异丙基氯化镁 作用下， 生成 苯酰胺,N-[(4-硝基苯甲酰)氧代]-
  参考文献：
  名称：

  Dornow et al., Justus Liebigs Annalen der Chemie, 1954, vol. 585, p. 220,225

  摘要：

  DOI：

文献信息

• Preparation and Characterization of Mixed Anhydrides of O-Acylarylcarbohydroximic Acid
  作者：Rajinder P. Sharma、Kusum Sharma、Sunita Lakhanpal、Namita Sharma、Bhupendra N. Misra

  DOI：10.1135/cccc19932150

  日期：——

  A number of N,O-diacylhydroxylamines have been prepared by the reaction of potassium salts of hydroxamic acids with variety of acylating agents which include: benzoyl, p-nitrobenzoyl, anisoyl, p-chlorobenzyl and lauroyl chlorides in dioxane under reflux. The structure of resulting N,O-diacylhydroxylamines has been determined by spectral analysis, Attempted have been made to prepare mixed anhydrides of several N,O-diacylhydroxylamines by the acylation reaction in the cold (below 10 °C) using acetyl, benzoyl, p-nitrobenzoyl, anisoyl and p-toluensulfonyl chlorides as acylating agents in dioxane using triethylamine as a base. Structures of the resulting mixed anhydrides have been elucidated by spectral methods.

  一些N,O-二酰基羟胺已经通过将羟肟酸钾盐与苯甲酰、对硝基苯甲酰、苯甲酰、对氯苯甲酰和月桂酰氯等多种酰化试剂在二氧六环中回流反应制备而成。通过光谱分析确定了所得N,O-二酰基羟胺的结构，尝试通过在冷却条件下（低于10°C）使用乙酰、苯甲酰、对硝基苯甲酰、苯甲酰和对甲苯磺酰氯作为酰化试剂，在二氧六环中使用三乙胺作为碱进行酰化反应，制备了几种N,O-二酰基羟胺的混合酸酐。通过光谱方法阐明了所得混合酸酐的结构。
• Synthesis of<i>N</i>-(acyloxy)-<i>N</i>-alkynylamides<i>via</i>generation of “C₂” from hypervalent alkynyliodane and a weak base
  作者：Kentaro Kagami、Xueying Liang、Nanako Ishibashi、Sayaka Ohrui、Masanori Tayu、Nozomi Saito

  DOI：10.1039/d3cc01403g

  日期：——

  conditions. This reaction probably involves biradical species (“C2”) generation and radical processes. Furthermore, we also demonstrated that N-(acyloxy)ynamide could be transformed into a N-sulfonylimidate derivative by a copper catalyst. This study provides new building blocks for synthetic organic chemistry reactions and improves understanding of the chemical reactivity of “C2”.

  通过N- (酰氧基)酰胺与高价炔基碘烷在温和条件下偶联，首次合成了N- (酰氧基)酰胺。该反应可能涉及双自由基物质（“C 2 ”）的产生和自由基过程。此外，我们还证明了N- (酰氧基)乙酰胺可以通过铜催化剂转化为N-磺酰亚胺酯衍生物。这项研究为合成有机化学反应提供了新的构建模块，并提高了对“C 2 ”化学反应性的理解。
• Singha, Journal of the Indian Chemical Society, 1989, vol. 66, # 2, p. 101 - 103
  作者：Singha

  DOI：——

  日期：——
• Werner; Skiba, Chemische Berichte, 1899, vol. 32, p. 1658
  作者：Werner、Skiba

  DOI：——

  日期：——
• Holleman, Recueil des Travaux Chimiques des Pays-Bas, 1897, vol. 16, p. 186
  作者：Holleman

  DOI：——

  日期：——