2-nitro-5-pyrrolidin-1-ylbenzaldehyde | 113259-80-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 2-nitro-5-pyrrolidin-1-ylbenzaldehyde
• 英文别名: 2-nitro-5-(1-pyrrolidinyl)benzaldehyde；2-Nitro-5-(pyrrolidin-1-yl)benzaldehyde
• CAS: 113259-80-6
• 化学式: C₁₁H₁₂N₂O₃
• 分子量: 220.228
• InChiKey: RBTIGMLMWOERDE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  66.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-nitro-5-pyrrolidin-1-ylbenzaldehyde 、 5-风化煤磷酸二乙酯 生成 (5Z)-5-[(2-nitro-5-pyrrolidin-1-ylphenyl)methylidene]imidazolidine-2,4-dione
  参考文献：
  名称：

  MEANWELL, NICHOLAS A.;WRIGHT, JOHN J.

  摘要：

  DOI：
• 作为产物：
  描述：

  5-氯-2-硝基苯甲醛 生成 2-nitro-5-pyrrolidin-1-ylbenzaldehyde
  参考文献：
  名称：

  MEANWELL, NICHOLAS A.;WRIGHT, JOHN J.

  摘要：

  DOI：

文献信息

• A One-Step Synthesis of 2,4-Unsubstituted Quinoline-3-carboxylic Acid Esters from <i>o</i>-Nitrobenzaldehydes
  作者：Hariharan Venkatesan、Frances M. Hocutt、Todd K. Jones、Michael H. Rabinowitz

  DOI：10.1021/jo100392x

  日期：2010.5.21

  straightforward and efficient one-step procedure for the synthesis of 2,4-unsubstituted quinoline-3-carboxylic acid ethyl esters is described. The simple reductive cyclization is carried out by treating various substituted o-nitrobenzaldehydes with inexpensive, commercially available 3,3-diethoxypropionic acid ethyl ester and SnCl2·2H2O in refluxing ethanol.

  描述了一种简单，有效的一步法合成2,4-未取代的喹啉-3-羧酸乙酯的方法。通过在回流的乙醇中用廉价的可商购的3，3-二乙氧基丙酸乙酯和SnCl 2 ·2H 2 O处理各种取代的邻硝基苯甲醛来进行简单的还原环化。
• 7-amino-1,3-dihydro-2H-imidazo[4,5-b]quinolin 2-ones and method for
  申请人：Bristol-Myers Company

  公开号：US04701459A1

  公开（公告）日：1987-10-20

  Novel series of 2,3-dihydro-2-oxo-1H-imidazo[4,5-b]quinolinyl amine derivatives of Formula ##STR1## wherein R.sub.1 is hydrogen, lower alkyl; R.sub.2 is hydrogen, lower alkyl, lower alkoxy, halogen; R.sub.3 is hydrogen, lower alkyl; R.sub.4 is hydrogen, lower alkyl, alkanoyl, phenylalkanoyl wherein phenyl is optionally substituted with halogen, lower alkyl, lower alkoxy; R.sub.3 and R.sub.4 are joined together to form morpholinyl, piperidinyl or pyrrolidinyl optionally substituted with --CO.sub.2 R.sub.5 or ##STR2## wherein R.sub.5 is hydrogen or lower alkyl, and R.sub.6 is hydrogen, lower alkyl, cycloalkyl; 4-R.sub.7 -piperazinyl wherein R.sub.7 is --CO.sub.2 R.sub.8 wherein R.sub.8 is lower alkyl, phenyl optionally substituted with up to 2 halogen, lower alkyl or lower alkoxy; phenylalkanoyl of 7 to 10 carbon wherein phenyl is unsubstituted or independently substituted with up to 2 halogen, lower alkyl, lower alkoxy. The compounds are cyclic AMP phosphodiesterase inhibitors and are particularly useful as inhibitors of blood platelet aggregation and/or as cardiotonic agents.

  2,3-二氢-2-氧基-1H-咪唑并[4,5-b]喹啉基胺衍生物的小说系列，化学式如下：其中R.sub.1是氢，较低的烷基；R.sub.2是氢，较低的烷基，较低的烷氧基，卤素；R.sub.3是氢，较低的烷基；R.sub.4是氢，较低的烷基，烷酰基，苯基烷酰基，其中苯基可以选择性地用卤素，较低的烷基，较低的烷氧基取代；R.sub.3和R.sub.4结合在一起形成吗啡啉基，哌啶基或吡咯啉基，可以选择性地用--CO.sub.2 R.sub.5或##STR2##取代，其中R.sub.5是氢或较低的烷基，R.sub.6是氢，较低的烷基，环烷基；4-R.sub.7-哌嗪基，其中R.sub.7是--CO.sub.2 R.sub.8，其中R.sub.8是较低的烷基，苯基，可以选择性地用最多2个卤素，较低的烷基或较低的烷氧基取代；含有7至10碳的苯基烷酰基，其中苯基未取代或独立地取代最多2个卤素，较低的烷基，较低的烷氧基。这些化合物是环磷酸腺苷磷酸二酯酶抑制剂，特别适用于抑制血小板聚集和/或作为心力补充剂。
• Aminoimidazoquinoline derivatives
  申请人：Bristol-Myers Squibb Company

  公开号：EP0252503A1

  公开（公告）日：1988-01-13

  Novel series of 2,3-dihydro-2-oxo-1H-imidazo­[4,5-b]quinolinyl amine derivatives of Formula wherein R₁ is hydrogen, lower alkyl; R₂ is hydrogen, lower alkyl, lower alkoxy, halogen; R₃ is hydrogen, lower alkyl; R₄ is hydrogen, lower alkyl, alkanoyl, phenylalkanoyl wherein phenyl is optionally substituted with halogen, lower alkyl, lower alkoxy; R₃ and R₄ are joined together to form morpholinyl, piperidinyl or pyrrolidinyl optionally substituted with -CO₂R₅ or -NR₅R₆ wherein R₅ is hydrogen or lower alkyl, and R₆ is hydrogen, lower alkyl, cycloalkyl; 4-R₇-piperazinyl wherein R₇ is -CO₂R₈ wherein R₈ is lower alkyl, phenyl optionally substituted with up to 2 halogen, lower alkyl or lower alkoxy; phenylalkanoyl of 7 to 10 carbon wherein phenyl is unsubstituted or independently substituted with up to 2 halogen, lower alkyl, lower alkoxy. The compounds are cyclic AMP phosphodiesterase inhibitors and are particularly useful as inhibitors of blood platelet aggregation and/or as cardiotonic agents.

  式中 2,3-二氢-2-氧代-1H-咪唑并[4,5-b]喹啉胺衍生物新系列 其中 R₁ 是氢、低级烷基；R₂ 是氢、低级烷基、低级烷氧基、卤素；R₃ 是氢、低级烷基；R₄ 是氢、低级烷基、烷酰基、苯基烷酰基，其中苯基可选择被卤素、低级烷基、低级烷氧基取代；R₃ 和 R₄ 连接在一起形成吗啉基、哌啶基或吡咯烷基，其中苯基可选择被 -CO₂R₅ 取代，或 -4-R₇-哌嗪基，其中 R₇ 是 -CO₂R₈ ，其中 R₈ 是低级烷基，苯基可选择被最多 2 个卤素、低级烷基或低级烷氧基取代；碳原子数为 7 至 10 的苯基烷酰基，其中苯基未被取代或独立地被最多 2 个卤素、低级烷基或低级烷氧基取代。这些化合物是环 AMP 磷酸二酯酶抑制剂，尤其可用作血小板聚集抑制剂和/或强心剂。
• MEANWELL, NICHOLAS A.;WRIGHT, JOHN J.
  作者：MEANWELL, NICHOLAS A.、WRIGHT, JOHN J.

  DOI：——

  日期：——
• US4701459A
  申请人：——

  公开号：US4701459A

  公开（公告）日：1987-10-20