phenyl 3-(6-chloropyridazin-3-yl)phenylcarbamate | 1010448-73-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: phenyl 3-(6-chloropyridazin-3-yl)phenylcarbamate
• 英文别名: phenyl N-[3-(6-chloropyridazin-3-yl)phenyl]carbamate
• CAS: 1010448-73-3
• 化学式: C₁₇H₁₂ClN₃O₂
• 分子量: 325.754
• InChiKey: QAWKOSWIBZSQRY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  64.1
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3-(6-氯哒嗪-3-基)苯胺 、 氯甲酸苯酯 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 21.0h， 以32%的产率得到phenyl 3-(6-chloropyridazin-3-yl)phenylcarbamate
  参考文献：
  名称：

  WO2008/30744

  摘要：

  公开号：

文献信息

• INHIBITORS OF C-MET AND USES THEREOF
  申请人：Bornmann William

  公开号：US20100144738A1

  公开（公告）日：2010-06-10

  The present invention relates to compounds and methods use as inhibitors of c-Met. Certain compounds of the subject invention have the following structural formula (I). Other compounds of the subject invention have structural formulas as defined herein. Also disclosed herein are pharmaceutical compositions comprising the compounds of the subject invention.

  本发明涉及化合物和方法，用作c-Met的抑制剂。本发明的某些化合物具有以下结构式（I）。本发明的其他化合物具有如此定义的结构式。本发明还揭示了包括本发明化合物的药物组合物。
• Kinase inhibitors for preventing or treating pathogen infection and method of use thereof
  申请人：Emory University

  公开号：EP2364702A2

  公开（公告）日：2011-09-14

  A composition is provided which comprises one or more Kinase inhibitors for use for preventing or treating a pathogenic infection caused by a broad array of pathogens in a patient in need thereof.

  本发明提供了一种组合物，其中包含一种或多种激酶抑制剂，用于预防或治疗由多种病原体引起的病原体感染。
• Kinase Inhibitors for Preventing or Treating Pathogen Infection and Method of Use Thereof
  申请人：Kalman Daniel

  公开号：US20100249122A1

  公开（公告）日：2010-09-30

  The present invention provides compositions and methods of use thereof to prevent and/or treat pathogenic infection. In particular, the present invention provides the use of kinase inhibitors to inhibit kinases that involve in pathogen-host cell interactions that are associated with or cause pathogenic infections, therefore, to effectively prevent and/or treat pathogenic infections with far less likely to engender resistance as compared to conventional antibiotics and anti-viral drugs. The present invention further provides the use of kinase inhibitors for the treatment of acute pathogenic infections for a short period of time to avoid toxicities that may caused by long term use of these kinase inhibitors.
• KINASE INHIBITORS FOR PREVENTING OR TREATING PATHOGEN INFECTION AND METHOD OF USE THEREOF
  申请人：Kalman Daniel

  公开号：US20120302565A1

  公开（公告）日：2012-11-29

  The present invention provides compositions and methods of use thereof to prevent and/or treat pathogenic infection. In particular, the present invention provides the use of kinase inhibitors to inhibit kinases that involve in pathogen-host cell interactions that are associated with or cause pathogenic infections, therefore, to effectively prevent and/or treat pathogenic infections with far less likely to engender resistance as compared to conventional antibiotics and anti-viral drugs. The present invention further provides the use of kinase inhibitors for the treatment of acute pathogenic infections for a short period of time to avoid toxicities that may caused by long term use of these kinase inhibitors.
• US8268809B2
  申请人：——

  公开号：US8268809B2

  公开（公告）日：2012-09-18