3-benzyloxy-4,5-dimethoxypicolinic acid | 234113-32-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 3-benzyloxy-4,5-dimethoxypicolinic acid
• 英文别名: 4,5-dimethoxy-3-phenylmethoxypyridine-2-carboxylic acid
• CAS: 234113-32-7
• 化学式: C₁₅H₁₅NO₅
• 分子量: 289.288
• InChiKey: WWSCINOZNCFWRN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  21
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  77.9
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  3-benzyloxy-4,5-dimethoxypicolinic acid 、 4-氨基二苯醚 生成 3-Hydroxy-4,5-dimethoxy-4'-phenoxypicolinanilide
  参考文献：
  名称：

  EP1134214

  摘要：

  公开号：
• 作为产物：
  描述：

  Methyl 3-benzyloxy-4,5-dimethoxypicolinate 在 sodium hydroxide 作用下， 以 甲醇 为溶剂， 生成 3-benzyloxy-4,5-dimethoxypicolinic acid
  参考文献：
  名称：

  EP1134214

  摘要：

  公开号：

文献信息

• Picolinamide derivative and harmful organism control agent comprising said picolinamide derivative as active component
  申请人：Meiji Seika Kaisha, Ltd.

  公开号：US07183278B1

  公开（公告）日：2007-02-27

  Disclosed are novel compounds useful for the control of harmful organisms, harmful organism control agents using the same, and processes for producing the novel compounds. The useful novel compounds according to the present invention include compounds represented by formula (1). The compounds represented by formula (1) have potent activity against harmful organisms, and do not have phytotoxicity against agricultural and gardening plants, as objects to which the compounds of the present invention are applied for preventive and exterminating purposes, and human beings and beasts wherein A represents a bond or an optionally substituted alkylene chain; R1 represents one or more groups, which may be the same or different, selected from the group consisting of a hydrogen atom, alkoxy, and haloalkoxy; R2 represents a hydrogen atom, benzyl, alkyl or alkanoyl, in which the groups other than the hydrogen atom may be substituted; and R3 represents a hydrogen atom, cycloalkyl, cycloalkenyl, aryl or a heterocyclic group, in which the groups other than the hydrogen atom may be substituted, excluding the case where R1 represents a hydrogen atom, A represents a bond or a methylene chain, and R3 represent phenyl or cyclohexyl, and the case where A represents an alkylene chain and R3 represents a hydrogen atom.

  本发明揭示了一种用于控制有害生物的新化合物，使用该化合物的有害生物控制剂以及制备该新化合物的方法。本发明中有用的新化合物包括由式（1）表示的化合物。式（1）表示的化合物对有害生物具有强效活性，并且不对农业和园艺植物产生植物毒性，作为本发明中应用于预防和灭除目的的对象，以及人类和动物。其中，A表示键或可选取代的烷基链；R1表示一个或多个基团，可以是相同或不同的，选自氢原子，烷氧基和卤代烷氧基；R2表示氢原子，苄基，烷基或烷酰基，其中除氢原子外的基团可以被取代；R3表示氢原子，环烷基，环烯基，芳基或杂环基，其中除氢原子外的基团可以被取代，但当R1表示氢原子，A表示键或亚甲基链，R3表示苯基或环己基时，以及当A表示烷基链，R3表示氢原子时，排除上述情况。
• NOVEL ANTIFUNGAL COMPOUNDS AND PROCESS FOR PRODUCING THE SAME
  申请人：Meiji Seika Kaisha, Ltd.

  公开号：EP1054011A1

  公开（公告）日：2000-11-22

  Disclosed are novel compounds useful for prevention or control of diseases derived from fungi, a process for producing the same, and novel antifungal agents using the novel compounds. The compounds useful for prevention and treatment of diseases derived from fungi according to the present invention include novel compounds represented by formula (I). The compounds represented by formula (I) have potent antifungal activity against diseases derived from fungi, and do not have phytotoxicity to mammals and agricultural and garden plants, from which diseases should be eliminated, and, even when applied to agricultural and garden plants, have high photostability. wherein R1 represents isobutyryl, tigloyl, isovaleryl, or 2-methylbutanoyl; R2 represents a hydrogen atom, an aromatic carboxylic acid residue, or a protective group of amino; and R3 represents a hydrogen atom, nitro, amino, acylamino, or N,N-dialkylamino, excluding the case where, when R1 represents isobutyryl, tigloyl, isovaleryl, or 2-methylbutanoyl with R3 representing a hydrogen atom, R2 represents a 3-hydroxypicolinic acid residue, 3-hydroxy-4-methoxypicolinic acid residue, or a 3,4-dimethoxypicolinic acid residue.

  本发明公开了用于预防或控制由真菌引起的疾病的新型化合物、生产新型化合物的工艺以及使用新型化合物的新型抗真菌剂。根据本发明，用于预防和治疗由真菌引起的疾病的化合物包括由式（I）代表的新型化合物。式 (I) 所代表的化合物对真菌引起的疾病有很强的抗真菌活性，对哺乳动物和农业及园林植物无植物毒性，可消除这些植物的疾病，即使应用于农业和园林植物，也具有很高的光稳定性。 其中 R1 代表异丁酰基、丁酰基、异戊酰基或 2-甲基丁酰基； R2 代表氢原子、芳香族羧酸残基或氨基保护基团；以及 R3 代表氢原子、硝基、氨基、酰氨基或 N,N-二烷基氨基，但不包括以下情况：当 R1 代表异丁酰基、虎杖酰基、异戊酰基或 2-甲基丁酰基且 R3 代表氢原子时，R2 代表 3-羟基吡啶羧酸残基、3-羟基-4-甲氧基吡啶羧酸残基或 3,4-二甲氧基吡啶羧酸残基。
• PICOLINAMIDE DERIVATIVES AND PEST CONTROLLERS CONTAINING THE SAME AS THE ACTIVE INGREDIENT
  申请人：Meiji Seika Kaisha, Ltd.

  公开号：EP1134214A1

  公开（公告）日：2001-09-19

  Disclosed are novel compounds useful for the control of harmful organisms, harmful organism control agents using the same, and processes for producing the novel compounds. The useful novel compounds according to the present invention include compounds represented by formula (1). The compounds represented by formula (1) have potent activity against harmful organisms, and do not have phytotoxicity against agricultural and gardening plants, as objects to which the compounds of the present invention are applied for preventive and exterminating purposes, and human beings and beasts. wherein A represents a bond or an optionally substituted alkylene chain; R1 represents one or more groups, which may be the same or different, selected from the group consisting of a hydrogen atom, alkoxy, and haloalkoxy; R2 represents a hydrogen atom, benzyl, alkyl or alkanoyl, in which the groups other than the hydrogen atom may be substituted; and R3 represents a hydrogen atom, cycloalkyl, cycloalkenyl, aryl or a heterocyclic group, in which the groups other than the hydrogen atom may be substituted, excluding the case where R1 represents a hydrogen atom, A represents a bond or a methylene chain, and R3 represent phenyl or cyclohexyl, and the case where A represents an alkylene chain and R3 represents a hydrogen atom.

  本发明公开了用于控制有害生物的新型化合物、使用这些化合物的有害生物控制剂以及生产这些新型化合物的工艺。根据本发明，有用的新型化合物包括由式（1）代表的化合物。式（1）代表的化合物对有害生物具有强效活性，并且对农业和园艺植物没有植物毒性，而农业和园艺植物是本发明化合物用于预防和消灭的对象，人类和野兽也是本发明化合物的对象。 其中 A 代表键或任选取代的亚烷基链；R1 代表一个或多个基团，它们可以相同或不同，选自由氢原子、烷氧基和卤代烷氧基组成的组；R2 代表氢原子、苄基、烷基或烷酰基，其中氢原子以外的基团可以被取代；以及 R3 代表氢原子、环烷基、环烯基、芳基或杂环基，其中氢原子以外的基团可被取代，但不包括 R1 代表氢原子、A 代表键或亚甲基链、R3 代表苯基或环己基的情况，以及 A 代表亚烷基链、R3 代表氢原子的情况。
• US7183278B1
  申请人：——

  公开号：US7183278B1

  公开（公告）日：2007-02-27
• US7250389B1
  申请人：——

  公开号：US7250389B1

  公开（公告）日：2007-07-31