3-carboxy-4-methylphenylsulphonyl hydrazide | 17641-51-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-carboxy-4-methylphenylsulphonyl hydrazide
• 英文别名: 5-(Hydrazinesulfonyl)-2-methylbenzoic acid
• CAS: 17641-51-9
• 化学式: C₈H₁₀N₂O₄S
• 分子量: 230.244
• InChiKey: OWVPVSGJLDEWBA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.2
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  118
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  3-carboxy-4-methylphenylsulphonyl hydrazide 在 吡啶 、 sodium hydroxide 作用下， 以 1,4-二氧六环 为溶剂， 反应 9.0h， 生成 2-(3'-carboxy-4'-methylphenylsulpho)-6-carboxymethoxy-3-(2H)-pyridazinone
  参考文献：
  名称：

  Purohit, D. M.; Shah, V. H., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1998, vol. 37, # 9, p. 956 - 960

  摘要：

  DOI：

文献信息

• Synthesis and antineoplastic activity of phenyl-substituted phenylsulfonylhydrazones of 1-pyridinecarboxaldehyde 1-oxide
  作者：William Loh、Lucille A. Cosby、Alan C. Sartorelli

  DOI：10.1021/jm00180a010

  日期：1980.6

  A variety of derivatives of 2-pyridinecarboxaldehyde 1-oxide benzenesulfonylhydrazone, containing substituents on the benzene or pyridine rings as well as on the nitrogen atom which is bonded directly to the sulfonyl group, have been synthesized. The antineoplastic activity of these compounds has been assessed in mice bearing either leukemia L1210 or P388. The most potent agents in this series were 2,4-dimethoxy,3,4-dimethoxy-, and 2,4,6-trimethylbenzenesulfonylhydrazone of 2-pyridinecarboxyaldehyde 1-oxide, all causing disappearance of tumors in 20-80% of leukemia-bearing mice.
• Purohit, D. M.; Shah, V. H., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1998, vol. 37, # 9, p. 956 - 960
  作者：Purohit, D. M.、Shah, V. H.

  DOI：——

  日期：——