1-acetyl-3-(E)-benzo[1,3]dioxol-5-ylmethylene-pyrrolidin-2-one | 1859-58-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并间二氧杂环戊烯类
• 英文名称: 1-acetyl-3-(E)-benzo[1,3]dioxol-5-ylmethylene-pyrrolidin-2-one
• 英文别名: (3E)-1-acetyl-3-(1,3-benzodioxol-5-ylmethylidene)pyrrolidin-2-one
• CAS: 1859-58-1
• 化学式: C₁₄H₁₃NO₄
• 分子量: 259.262
• InChiKey: ZZBFDCIZPLTFNE-IZZDOVSWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  55.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-acetyl-3-(E)-benzo[1,3]dioxol-5-ylmethylene-pyrrolidin-2-one 生成 trans-1-Acetyl-3-<4.5-methylendioxy-2-nitro-benzyliden>-pyrrolidon-(2)
  参考文献：
  名称：

  Lichtinduzierte合成von 2,3-dihydropyrrolo [2,3-b] chinolinen and carbostyrilen aus 1-acetyl-trans-3-（2-aminomethoxyiden）-pyrrolidonen-（2）

  摘要：

  DOI：

  10.1016/s0040-4039(01)88612-3

文献信息

• HEAT SHOCK FACTOR ACTIVITY INHIBITORS
  申请人：Kaneka Corporation

  公开号：EP0995745A1

  公开（公告）日：2000-04-26

  A disease treatment is provided by controlling the expression of a protein induced by a heat shock factor. The novel compound benzo-1,3-dioxole provides an inhibitor of HSF activity or an inhibitor of inducing the production of a protein regulated by HSF, which inhibits the activity of a heat shock factor, a transcriptional regulatory factor, thereby in turn inhibiting transcription of a structural gene having a heat shock element sequence in the gene region for transcriptional regulation into RNA, and thus inhibiting translation of the gene into a protein, and resulting in inhibition of inducing production of RNA or protein encoded by the gene. It also provides a drug for treating or preventing cancer through thermotherapy and a drug for treating or preventing stress diseases such as depression.

  通过控制由热休克因子诱导的蛋白质的表达，提供了一种疾病治疗方法。 本发明的新型化合物苯并-1,3-二氧戊环提供了一种热休克因子活性抑制剂或热休克因子调控蛋白的诱导产生抑制剂，它能抑制热休克因子这一转录调控因子的活性，从而反过来抑制基因区中具有热休克元件序列的结构基因转录为RNA，进行转录调控，进而抑制基因翻译成蛋白质，导致抑制诱导产生该基因编码的RNA或蛋白质。它还提供了一种通过热疗治疗或预防癌症的药物，以及一种治疗或预防抑郁症等应激性疾病的药物。
• Heat shock factor activity inhibitor
  申请人：——

  公开号：US20020058679A1

  公开（公告）日：2002-05-16

  A disease treatment is provided by controlling the expression of a protein induced by a heat shock factor. The novel compound benzo-1,3-dioxole provides an inhibitor of HSF activity or an inhibitor of inducing the production of a protein regulated by HSF, which inhibits the activity of a heat shock factor, a transcriptional regulatory factor, thereby in turn inhibiting transcription of a structural gene having a heat shock element sequence in the gene region for transcriptional regulation into RNA, and thus inhibiting translation of the gene into a protein, and resulting in inhibition of inducing production of RNA or protein encoded by the gene. It also provides a drug for treating or preventing cancer through thermotherapy and a drug for treating or preventing stress diseases such as depression.

  通过控制由热休克因子诱导的蛋白质的表达，提供了一种疾病治疗方法。 本发明的新型化合物苯并-1,3-二氧戊环提供了一种热休克因子活性抑制剂或热休克因子调控蛋白的诱导产生抑制剂，它能抑制热休克因子这一转录调控因子的活性，从而反过来抑制基因区中具有热休克元件序列的结构基因转录为RNA，进行转录调控，进而抑制基因翻译成蛋白质，导致抑制诱导产生该基因编码的RNA或蛋白质。它还提供了一种通过热疗治疗或预防癌症的药物，以及一种治疗或预防抑郁症等应激性疾病的药物。
• Methods of treating cancer using a heat shock factor activity inhibitor
  申请人：——

  公开号：US20030149077A1

  公开（公告）日：2003-08-07

  A disease treatment is provided by controlling the expression of a protein induced by a heat shock factor. The novel compound benzo-1,3-dioxole provides an inhibitor of HSF activity or an inhibitor of inducing the production of a protein regulated by HSF, which inhibits the activity of a heat shock factor, a transcriptional regulatory factor, thereby in turn inhibiting transcription of a structural gene having a heat shock element sequence in the gene region for transcriptional regulation into RNA, and thus inhibiting translation of the gene into a protein, and resulting in inhibition of inducing production of RNA or protein encoded by the gene. It also provides a drug for treating or preventing cancer through thermotherapy and a drug for treating or preventing stress diseases such as depression.

  通过控制由热休克因子诱导的蛋白质的表达，提供了一种疾病治疗方法。 本发明的新型化合物苯并-1,3-二氧戊环提供了一种热休克因子活性抑制剂或热休克因子调控蛋白的诱导产生抑制剂，它能抑制热休克因子这一转录调控因子的活性，从而反过来抑制基因区中具有热休克元件序列的结构基因转录为RNA，进行转录调控，进而抑制基因翻译成蛋白质，导致抑制诱导产生该基因编码的RNA或蛋白质。它还提供了一种通过热疗治疗或预防癌症的药物，以及一种治疗或预防抑郁症等应激性疾病的药物。
• US6281229B1
  申请人：——

  公开号：US6281229B1

  公开（公告）日：2001-08-28
• US6613780B2
  申请人：——

  公开号：US6613780B2

  公开（公告）日：2003-09-02