N-乙基-2-溴-4-硝基苯胺 | 108485-08-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: N-乙基-2-溴-4-硝基苯胺
• 中文别名: N-乙基2-溴-4-硝基苯胺
• 英文名称: N-ethyl-2-bromo-4-nitro-aniline
• 英文别名: N-Aethyl-2-brom-4-nitro-anilin；2-Bromo-N-ethyl-4-nitroaniline
• CAS: 108485-08-1
• 化学式: C₈H₉BrN₂O₂
• mdl: MFCD12044149
• 分子量: 245.076
• InChiKey: XGXMCUACVIEWKI-UHFFFAOYSA-N

物化性质

• 熔点：
  65-66 °C(Solv: ethanol (64-17-5))
• 沸点：
  338.5±32.0 °C(Predicted)
• 密度：
  1.597±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  57.8
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2921420090

SDS

Material Safety Data Sheet

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Section 1. Identification of the substance
Product Name: N-Ethyl 2-bromo-4-nitroaniline
Synonyms: 2-Bromo-N-ethyl-4-nitroaniline

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Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

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Section 3. Composition/information on ingredients.
Ingredient name: N-Ethyl 2-bromo-4-nitroaniline
CAS number: 108485-08-1

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Section 4. First aid measures
Skin contact: Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

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Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

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Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

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Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels.
Storage:

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Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

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Section 9. Physical and chemical properties
Appearance: Not specified
Boiling point: No data
No data
Melting point:
Flash point: No data
Density: No data
Molecular formula: C8H9BrN2O2
Molecular weight: 245.1

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Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, hydrogen bromide.

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Section 11. Toxicological information
No data.

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Section 12. Ecological information
No data.

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Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

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Section 14. Transportation information
Non-harzardous for air and ground transportation.

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Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为产物：
  描述：

  N-乙基-对-硝基苯胺 在 溴 、 溶剂黄146 作用下， 生成 N-乙基-2-溴-4-硝基苯胺
  参考文献：
  名称：

  A Proteomic Approach to the Identification of Lung Cancer Markers

  摘要：

  我们已经开发了一种全面的方法来识别肺癌中的蛋白标记物，包括肿瘤组织和细胞系的分析，以及血清中自身抗体对肺肿瘤抗原的分析。通过质谱法已经鉴定了在肺癌主要亚型中差异表达的大量蛋白质。已构建了一个蛋白质在肺癌和其他类型癌症中的表达数据库，集成了二维凝胶轮廓、质谱数据、定量蛋白数据和RNA水平的基因表达数据，作为生物标志物识别的资源。对肺癌患者血清中的免疫反应进行分析，已经发现了在诊断时可在肺癌患者血清中检测到的新标记物。蛋白质组学方法可能会产生新的分类方案和早期诊断肺癌的新标记物。

  DOI：

  10.1155/2001/657605

文献信息

• A Proteomic Approach to the Identification of Lung Cancer Markers
  作者：Samir Hanash、Franck Brichory、David Beer

  DOI：10.1155/2001/657605

  日期：——

  We have developed a comprehensive approach to the identification of protein markers in lung cancer that includes profiling of tumor tissue and cell lines as well as the analysis of serum for autoantibodies to lung tumor antigens. A large number of proteins that are differentially expressed in the major subtypes of lung cancer have been identified by mass spectrometry. A database of protein expression in lung cancer and other types of cancer has been constructed that integrates two-dimensional gel profiles, mass spectrometry data, quantitative protein data and gene expression data at the RNA level, that serves as a resource for biomarker identification. Analysis of the serological response in lung cancer has led to the identification of novel markers detectable in serum of lung cancer patients at the time of diagnosis. The proteomic approach is likely to yield novel classification schemes and novel markers for early diagnosis of lung cancer.

  我们已经开发了一种全面的方法来识别肺癌中的蛋白标记物，包括肿瘤组织和细胞系的分析，以及血清中自身抗体对肺肿瘤抗原的分析。通过质谱法已经鉴定了在肺癌主要亚型中差异表达的大量蛋白质。已构建了一个蛋白质在肺癌和其他类型癌症中的表达数据库，集成了二维凝胶轮廓、质谱数据、定量蛋白数据和RNA水平的基因表达数据，作为生物标志物识别的资源。对肺癌患者血清中的免疫反应进行分析，已经发现了在诊断时可在肺癌患者血清中检测到的新标记物。蛋白质组学方法可能会产生新的分类方案和早期诊断肺癌的新标记物。