2-aminoethanethiol t-butyl disulfide hydrochloride

• 分子结构分类: 有机化合物 - 有机硫化合物 - 有机二硫化物
• 英文名称: 2-aminoethanethiol t-butyl disulfide hydrochloride
• 英文别名: 2-(Tert-butyldisulfanyl)ethylazanium;chloride；2-(tert-butyldisulfanyl)ethylazanium;chloride
• 化学式: C₆H₁₅NS₂*ClH
• 分子量: 201.785
• InChiKey: BKRREUFABWFQRH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.55
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  76.6
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-aminoethanethiol t-butyl disulfide hydrochloride 在 双氧水 作用下， 生成 Di-tert-butyl vic-disulfone
  参考文献：
  名称：

  Organic Disulfides and Related Substances. VIII. Preparation and Oxidation of Some Unsymmetrical Dialkyl and Alkyl Pyridinium Disulfides¹

  摘要：

  DOI：

  10.1021/jo01029a510
• 作为产物：
  描述：

  1-t-butylthiohydrazine-1,2-dicarboxmorpholide 生成 2-aminoethanethiol t-butyl disulfide hydrochloride
  参考文献：
  名称：

  MORODER, LUIS;GOBBO, MARINA;BECKER, GERHARD;WUNSCH, ERICH, BIOL. CHEM./HOPPE-SEYLER., 370,(1989) N, C. 365-375

  摘要：

  DOI：

文献信息

• PRODUCTION METHOD FOR NONCYCLIC PEPTIDE-NUCLEIC ACID COMPLEX HAVING, AT N-TERMINAL, AMINO ACID WITH THIOL GROUP NEAR AMINO GROUP, LIBRARY THEREOF, AND CYCLIC PEPTIDE-NUCLEIC ACID COMPLEX LIBRARY DERIVED FROM SAME
  申请人：Chugai Seiyaku Kabushiki Kaisha

  公开号：EP3424941A1

  公开（公告）日：2019-01-09

  When the initiation suppression method was used for translation of a peptide having at its N terminus an amino acid residue carrying a thiol group near its amino group with specific protecting groups being introduced to the thiol group and the amino group, it was found that not only the probability of initiation of amino acid translation reaction was improved, but also production of cleaved peptides was suppressed and translation efficiency and purity were improved. Furthermore, it was found that it is possible to efficiently promote the cyclization reaction of the peptide through amide bond formation. Based on these findings, the inventors discovered novel methods for preparing complexes between nucleic acids and peptides containing various unnatural amino acids and having an amide bond-mediated cyclized portion.

  当使用起始抑制法翻译 N 端在氨基附近带有硫醇基的氨基酸残基并在硫醇基和氨基上引入特定保护基团的多肽时，发现不仅提高了氨基酸翻译反应的起始概率，而且抑制了裂解肽的产生，提高了翻译效率和纯度。此外，还发现可以通过酰胺键的形成有效促进肽的环化反应。基于这些发现，发明人发现了制备核酸与含有各种非天然氨基酸并具有酰胺键介导的环化部分的肽之间的复合物的新方法。
• Synthesis and evaluation of a library of peptidomimetics based upon the β-turn
  作者：Alex A. Virgilio、Andrew A. Bray、Wei Zhang、Lon Trinh、Michael Snyder、Michael M. Morrissey、Jonathan A. Ellman

  DOI：10.1016/s0040-4020(97)00221-4

  日期：1997.5

  A diverse library of 11.52 compounds based on a beta-turn mimetic scaffold was synthesized. A subset of the library was characterized by ES-MS. Several compounds from the library with modest affinity to a cloned N-formyl-Mer-Leu-Phe (fMLF) receptor were identified. (C) 1997 Published by Elsevier Science Ltd.
• MORODER, LUIS;GOBBO, MARINA;BECKER, GERHARD;WUNSCH, ERICH, BIOL. CHEM./HOPPE-SEYLER., 370,(1989) N, C. 365-375
  作者：MORODER, LUIS、GOBBO, MARINA、BECKER, GERHARD、WUNSCH, ERICH

  DOI：——

  日期：——
• ANTIBODY-COMB POLYMER CONJUGATE
  申请人：UCB Pharma, S.A.

  公开号：EP1926757B1

  公开（公告）日：2012-02-22
• COMB POLYMERS
  申请人：UCB Pharma, S.A.

  公开号：EP1926757A1

  公开（公告）日：2008-06-04