[(2S,3S,5R)-3-azido-5-(5-azido-2,4-dioxo-pyrimidin-1-yl)tetrahydrofuran-2-yl]methyl dihydrogen phosphate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: [(2S,3S,5R)-3-azido-5-(5-azido-2,4-dioxo-pyrimidin-1-yl)tetrahydrofuran-2-yl]methyl dihydrogen phosphate
• 英文别名: [(2S,3S,5R)-3-azido-5-(5-azido-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl dihydrogen phosphate
• 化学式: C9H11N8O7P
• 分子量: 374.21
• InChiKey: OQIWJZWKSBHJRD-UBKIQSJTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  154
• 氢给体数：
  3
• 氢受体数：
  11

文献信息

• Pharmaceutical compositions and method for the treatment of retroviral infections
  申请人：——

  公开号：US20030187003A1

  公开（公告）日：2003-10-02

  The invention provides the use of a pyrano[2,3-d:6,5-d′] dipyrimidine derivative for the manufacture of a medicine for the treatment of a retroviral infection in a mammal. It also provides a product containing: (a) one or more derivatives of a pyrano[2,3-d:6,5-d′] dipyrimidine; and (b) one or more anti-retroviral drugs, including drugs effective against one or more retroviral or cellular proteins involved in the entry and/or replication of a retrovirus, in respective proportions such as to provide a synergistic effect against a retroviral infection in a mammal, as a combined preparation for simultaneous, separate or sequential use in retroviral infection therapy.

  本发明提供了一种吡喃[2,3-d:6,5-d′]二嘧啶衍生物用于制造治疗哺乳动物逆转录病毒感染的药物。 它还提供了一种含有以下成分的产品：(a) 一种或多种吡喃[2,3-d： 6,5-d′]二嘧啶的一种或多种衍生物；以及(b)一种或多种抗逆转录病毒药物，包括对参与逆转录病毒进入和/或复制的一种或多种逆转录病毒或细胞蛋白有效的药物，其各自的比例应能对哺乳动物的逆转录病毒感染产生协同作用，作为一种组合制剂，可同时、单独或依次用于逆转录病毒感染治疗。
• PHARMACEUTICAL COMPOSITION AND METHOD FOR THE TREATMENT OF RETROVIRAL INFECTIONS
  申请人：Stichting REGA V.Z.W.

  公开号：EP1309349A2

  公开（公告）日：2003-05-14
• [EN] PHARMACEUTICAL COMPOSITION AND METHOD FOR THE TREATMENT OF RETROVIRAL INFECTIONS<br/>[FR] COMPOSITION PHARMACEUTIQUE ET TECHNIQUE DE TRAITEMENT DES INFECTIONS RETROVIRALES
  申请人：——

  公开号：WO2002003971A2

  公开（公告）日：2002-01-17

  [EN] The invention provides the use of a pyrano[2,3-d:6,5-d'] dipyrimidine derivative for the manufacture of a medicine for the treatment of a retroviral infection in a mammal. It also provides a product containing: (a) one or more derivatives of a pyrano[2,3-d:6,5-d'] dipyrimidine; and (b) one or more anti-retroviral drugs, including drugs effective against one or more retroviral or cellular proteins involved in the entry and/or replication of a retrovirus, in respective proportions such as to provide a synergistic effect against a retroviral infection in a mammal, as a combined preparation for simultaneous, separate or sequential use in retroviral infection therapy.
  [FR] La présente invention concerne l'utilisation d'un dérivé de pyrano[2,3-d:6,5-d'] dipyrimidine destiné à la fabrication d'un médicament pour le traitement d'une infection rétrovirale chez un mammifère. Cette invention concerne aussi un produit contenant: (a) un ou plusieurs dérivés de pyrano[2,3-d:6,5-d'] dipyrimidine, et (b) un ou plusieurs médicaments dirigés contre les rétrovirus, comprenant des médicaments efficaces contre une ou plusieurs protéines rétrovirales ou cellulaires impliquées dans la pénétration et/ou la réplication d'un rétrovirus, en proportions respectives de façon à offrir un effet synergique contre une infection rétrovirale chez un mammifère, sous forme de préparation combinée en vue d'une utilisation simultanée, distincte ou séquentielle dans une thérapie de lutte contre une infection rétrovirale.
• [EN] A PHARMACEUTICAL COMPOSITION AND A METHOD FOR THE TREATMENT OF RETROVIRUS-INFECTED PATIENTS<br/>[FR] COMPOSITION PHARMACEUTIQUE ET TRAITEMENT DE PATIENTS INFECTES PAR UN RETROVIRUS
  申请人：LEUVEN K U RES & DEV

  公开号：WO2002051419A2

  公开（公告）日：2002-07-04

  A benzopyrano-oxopyrimidotetrahydrothiazine or derivative thereof having formula (I) wherein: R1 is selected from hydrogen and halo, and R2 is selected from hydrogen, halo, hydroxy and methoxy, is useful as an inhibitor of a retroviral enzyme, namely HIV integrase, as an active ingredient for the treatment of retroviral infection in humans and mammals.