2-ethyl-N-phenethylbenzamide | 1085539-91-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-ethyl-N-phenethylbenzamide
• 英文别名: 2-ethyl-N-(2-phenylethyl)benzamide
• CAS: 1085539-91-8
• 化学式: C₁₇H₁₉NO
• 分子量: 253.344
• InChiKey: UHMVDSQCUXQZTP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  N-(2-phenylethyl)phthalimide 、 diethylzinc 在 2,2'-联吡啶 、 bis(acetylacetonate)nickel(II) 作用下， 以 1,4-二氧六环 为溶剂， 反应 16.0h， 以85%的产率得到2-ethyl-N-phenethylbenzamide
  参考文献：
  名称：

  Nickel-Mediated Decarbonylative Cross-Coupling of Phthalimides with in Situ Generated Diorganozinc Reagents

  摘要：

  The nickel-mediated cross-coupling of phthalimides with diorganozinc reagents proceeds via a decarbonylative process to produce ortho-substituted benzamides in high yields. In addition to tolerating diverse phthalimide functionality, including alkyl, aryl, and heteroatom containing substituents, this methodology proceeds smoothly with diorganozinc reagents prepared from aryl bromides and utilized without purification.

  DOI：

  10.1021/jo200347j

文献信息

• Nickel-Mediated Decarbonylative Cross-Coupling of Phthalimides with in Situ Generated Diorganozinc Reagents
  作者：Sarah E. Havlik、Jessica M. Simmons、Valerie J. Winton、Jeffrey B. Johnson

  DOI：10.1021/jo200347j

  日期：2011.5.6

  The nickel-mediated cross-coupling of phthalimides with diorganozinc reagents proceeds via a decarbonylative process to produce ortho-substituted benzamides in high yields. In addition to tolerating diverse phthalimide functionality, including alkyl, aryl, and heteroatom containing substituents, this methodology proceeds smoothly with diorganozinc reagents prepared from aryl bromides and utilized without purification.