N,N'-bis(pyridin-3-ylmethyl)pyrimidine-4,6-dicarboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: N,N'-bis(pyridin-3-ylmethyl)pyrimidine-4,6-dicarboxamide
• 英文别名: 4-N,6-N-bis(pyridin-3-ylmethyl)pyrimidine-4,6-dicarboxamide
• 化学式: C₁₈H₁₆N₆O₂
• 分子量: 348.4
• InChiKey: NHPBWKYFMTXWAA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  110
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• Targeted Drug Conjugates
  申请人：Philochem AG

  公开号：US20170028080A1

  公开（公告）日：2017-02-02

  A targeted therapeutic agent comprising a compound of formula: B-L-D wherein: B is a non-internalizing binding moiety specific for a cancer associated protein; D is a cytotoxic drug moiety; and L is a linker group that undergoes cleavage in vivo for releasing said drug moiety in an active form. The binding moiety is a ligand for the cancer associated protein whereby drawbacks associated with the use of internalizing ligands are avoided.
• IDENTIFICATION AND TARGETED MODULATION OF GENE SIGNALING NETWORKS
  申请人：CAMP4 THERAPEUTICS CORPORATION

  公开号：US20210254056A1

  公开（公告）日：2021-08-19

  The present invention provides methods and compositions for the evaluation, alteration and/or optimization of gene signaling. Methods and systems are also provided which exploit the information generated in the identification of new targets and non-canonical signaling pathways.