6-(4-methylphenyl)-1-bromohexane | 79654-72-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 6-(4-methylphenyl)-1-bromohexane
• 英文别名: 1-(6-bromohexyl)-4-methylbenzene；1-(6-Brom-hexyl)-4-methyl-benzol；6-(p-tolyl)hexyl bromide
• CAS: 79654-72-1
• 化学式: C₁₃H₁₉Br
• 分子量: 255.198
• InChiKey: KPHMFAVMIDDTKL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  6-(4-methylphenyl)-1-bromohexane 在 potassium cyanide 作用下， 生成 7-(对甲苯基)庚酸
  参考文献：
  名称：

  Huisgen; Vossius, Monatshefte fur Chemie, 1957, vol. 88, p. 517,527

  摘要：

  DOI：
• 作为产物：
  描述：

  6-bromo-1-(p-tolyl)hexan-1-one 在 三乙基硅烷 作用下， 反应 0.67h， 生成 6-(4-methylphenyl)-1-bromohexane
  参考文献：
  名称：

  Synthesis of neuroprotective cyclopentenone prostaglandin analogs: Suppression of manganese-induced apoptosis of PC12 cells

  摘要：

  The synthesis and evaluation for anti- and proapoptotic properties of cyclopenterione prostaglandin analogs are described. Novel J-type analogs of NEPP11 with a cross-conjugated cyclopentadienone moiety and a lipophilic omega-side chain suppressed manganese ion-induced apoptosis of PC12 cells at comparable levels to NEPP11, while monoenone derivatives were inactive. The proapoptotic activities of J-type analogs were much lower than that of NEPP11. Natural 15-deoxy-Delta(12,14)-PGJ(2) and Delta(7)-PGA(1) methyl ester were highly toxic, inducing apoptosis at lower concentrations. (C) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.12.004

文献信息

• Methylenedioxyphenyl substituted aliphatic diketones
  申请人：Sterling Drug, Inc.

  公开号：US04093736A1

  公开（公告）日：1978-06-06

  Aryl substituted diketones and keto-esters, useful as antiviral agents and insecticides, are prepared by reacting an arylalkyl or arylalkenyl iodide with a metal salt of the appropriate diketone or keto-ester.

  芳基取代的二酮和酮酯，可用作抗病毒剂和杀虫剂，通过将芳基烷基或芳基烯基碘化物与适当的二酮或酮酯的金属盐反应制备。
• Aryl substituted diketones
  申请人：Sterling Drug Inc.

  公开号：US04171378A1

  公开（公告）日：1979-10-16

  Aryl substituted diketones and keto-esters, useful as antiviral agents and insecticides, are prepared by reacting an arylalkyl or arylalkenyl iodide with a metal salt of the appropriate diketone or keto-ester.

  芳基取代的二酮和酮酯，可作为抗病毒剂和杀虫剂使用，通过将芳基烷基或芳基烯基碘化物与适当的二酮或酮酯的金属盐反应制备而成。
• Concise Synthesis of a New Chiral Cyclopentenone Building Block for Prostaglandins and their Derivatives
  作者：Remigiusz Żurawiński、Beata Łukasik

  DOI：10.1002/ejoc.201900102

  日期：2019.4.24

  A facile four‐step protocol for the preparation of a new chiral phosphonate building block is reported. Its exemplary functionalization at the C2 and C3 carbon atoms via the Wittig‐Horner reaction and by the Michael addition of organometallic reagents, respectively, is demonstrated as well.

  报道了一种用于制备新的手性膦酸酯结构单元的简便的四步方案。还证明了其分别通过Wittig-Horner反应和通过有机金属试剂的迈克尔加成在C2和C3碳原子上的示例性官能化。
• Process for preparing 1-bromoalkylbenzene derivatives and intermediates thereof
  申请人：SUMITOMO CHEMICAL COMPANY LIMITED

  公开号：EP0637580A1

  公开（公告）日：1995-02-08

  A 1-bromoalkylbenzene derivative is prepared by reacting a phenylalkene derivative with hydrogen bromide in the presence of a non-polar solvent. The phenylalkene derivative is prepared by reacting an alkenyl halide with metal magnesium to form a Grignard reagent, and then reacting the Grignard reagent with a benzyl halide derivative. An allyl Grignard reagent is prepared by reacting continuously an allyl halide derivative with metal magnesium in an organic solvent, in which the allyl halide derivative and metal magnesium are continuously added to the reaction system and the allyl Grignard reagent formed is continuously removed from the reaction system. The processes provide the intended compounds in high yields, high selectivities and high purities.

  1-bromoalkylbenzene derivative is prepared by reacting a phenylalkene derivative with hydrogen bromide in the presence of a non-polar solvent.苯基烷烃衍生物的制备方法是先使烯基卤化物与金属镁反应生成格氏试剂，然后使格氏试剂与苄基卤化物衍生物反应。烯丙基格氏试剂是通过烯丙基卤化物衍生物与金属镁在有机溶剂中连续反应制备的，其中烯丙基卤化物衍生物和金属镁被连续加入反应体系，形成的烯丙基格氏试剂被连续从反应体系中移除。这些工艺可提供高产率、高选择性和高纯度的预期化合物。
• JAXA-CHAMIEC, ALBERT;SHAH, VIRENDRA P.;KRUSE, LAWRENCE I., J. CHEM. SOC. PERKIN TRANS. PT 1,(1989) N, C. 1705-1706
  作者：JAXA-CHAMIEC, ALBERT、SHAH, VIRENDRA P.、KRUSE, LAWRENCE I.

  DOI：——

  日期：——