N-benzyl-N-(1-cyclopropylethyl)acetamide | 255713-86-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-benzyl-N-(1-cyclopropylethyl)acetamide
• CAS: 255713-86-1
• 化学式: C₁₄H₁₉NO
• mdl: MFCD00661895
• 分子量: 217.311
• InChiKey: KKNCMPFBSNHOCN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N-benzyl-N-(1-cyclopropylethyl)acetamide 在 PPA 作用下， 反应 6.0h， 以80%的产率得到N-acetyl-4-ethyl-3-methyl-1,2,3,4-tetrahydroisoquinoline
  参考文献：
  名称：

  A SIMPLE AND EFFICIENT PREPARATION OF 3,4-DIALKYLSUBSTITUTED TETRAHYDROISOQUINOLINE USING CYCLOPROPYLETHYLIDEN BENZYLAMINE

  摘要：

  Intramolecular Friedel-Crafts alkylation of N-benzyl-N-(1-cyclopropylethyl)acetamide to 3,4-dialkyl substituted tetrahydroisoquinoline by reaction of the acetamide with ail excess of PPA is described. The conformational study of intermediates by high resolution NMR analysis is also reported.

  DOI：

  10.1081/scc-120012985
• 作为产物：
  描述：

  N-benzyl-N-(1-cyclopropylethylidene)amine 在 sodium tetrahydroborate 作用下， 以 甲醇 为溶剂， 生成 N-benzyl-N-(1-cyclopropylethyl)acetamide
  参考文献：
  名称：

  A SIMPLE AND EFFICIENT PREPARATION OF 3,4-DIALKYLSUBSTITUTED TETRAHYDROISOQUINOLINE USING CYCLOPROPYLETHYLIDEN BENZYLAMINE

  摘要：

  Intramolecular Friedel-Crafts alkylation of N-benzyl-N-(1-cyclopropylethyl)acetamide to 3,4-dialkyl substituted tetrahydroisoquinoline by reaction of the acetamide with ail excess of PPA is described. The conformational study of intermediates by high resolution NMR analysis is also reported.

  DOI：

  10.1081/scc-120012985

文献信息

• A SIMPLE AND EFFICIENT PREPARATION OF 3,4-DIALKYLSUBSTITUTED TETRAHYDROISOQUINOLINE USING CYCLOPROPYLETHYLIDEN BENZYLAMINE
  作者：Vladimir Kouznetsov、Alirio Palma、Wilson Rozo、Elena Stashenko、Alí Bahsas、Juan Amaro-Luis

  DOI：10.1081/scc-120012985

  日期：2002.1

  Intramolecular Friedel-Crafts alkylation of N-benzyl-N-(1-cyclopropylethyl)acetamide to 3,4-dialkyl substituted tetrahydroisoquinoline by reaction of the acetamide with ail excess of PPA is described. The conformational study of intermediates by high resolution NMR analysis is also reported.