tetramethylbarbituric acid | 13566-66-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: tetramethylbarbituric acid
• 英文别名: 1,3,5,5-tetramethyl-pyrimidine-2,4,6-trione；1,3,5,5-tetramethyl-barbituric acid；1,3,5,5-Tetramethyl-barbitursaeure；1,3,5,5-Tetramethyl-1,3-diazinane-2,4,6-trione
• CAS: 13566-66-0
• 化学式: C₈H₁₂N₂O₃
• mdl: MFCD00596765
• 分子量: 184.195
• InChiKey: WRZUGXZYPUJUOL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.625
• 拓扑面积：
  57.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  正己烷 、 1,3-二甲基巴比妥 、 tetramethylbarbituric acid 生成 苯
  参考文献：
  名称：

  SLESAREV, V. I.;KRASNOV, K. A.;ZAXAROV, A. P.;SOLOVEV, V. I.

  摘要：

  DOI：
• 作为产物：
  描述：

  重氮甲烷 、 5,5-二甲基丙二酰脲 生成 tetramethylbarbituric acid
  参考文献：
  名称：

  Stuckey, Quarterly Journal of Pharmacy and Pharmacology, 1942, vol. 15, p. 377,379

  摘要：

  DOI：

文献信息

• PYRIMIDINE-2,4,6-TRIONES FOR USE IN THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS
  申请人：Cambria Pharmaceuticals, Inc.

  公开号：EP3144299A1

  公开（公告）日：2017-03-22

  The present invention relates to the identification of inventive pyrimidine-2,4,6- triones (PYT compounds) of formula (I) and pharmaceutical compositions thereof for treating subjects with amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. The invention also provides methods of preparing the inventive PYT compounds.

  本发明涉及式（I）的发明性嘧啶-2,4,6-三酮（PYT化合物）及其药物组合物的鉴定，用于治疗肌萎缩性脊髓侧索硬化症（ALS）和其他神经退行性疾病。本发明还提供了制备本发明PYT化合物的方法。
• Electrolyte and electrochemical device
  申请人：NINGDE AMPEREX TECHNOLOGY LIMITED

  公开号：US11031630B2

  公开（公告）日：2021-06-08

  The present application provides an electrolyte and an electrochemical device. The electrolyte according to the present application comprises a carboxylate, a barbituric acid compound and a nitrile compound. Adding a barbituric acid compound and a nitrile compound of particular structure to an electrolyte containing a carboxylate solvent can significantly improve the rate performance of an electrochemical device, and mitigate capacity loss after storage at room temperature, and cycle fading and gas generation at high-temperature of the electrochemical device.

  本申请提供了一种电解质和一种电化学装置。根据本申请，电解液由羧酸盐、巴比妥酸化合物和腈化合物组成。在含有羧酸盐溶剂的电解液中添加具有特定结构的巴比妥酸化合物和腈化合物，可显著提高电化学装置的速率性能，并可减轻电化学装置在室温储存后的容量损失以及高温下的循环衰减和气体生成。
• Thermophysical Study of Several Barbituric Acid Derivatives by Differential Scanning Calorimetry (DSC)
  作者：Manuel Temprado、María Victoria Roux、Francisco Ros、Rafael Notario、Marta Segura、James S. Chickos

  DOI：10.1021/je1008944

  日期：2011.2.10

  The present study reports a differential scanning calorimetry (DSC) study of the barbituric acid derivatives: 1,3-dimethylbarbituric acid [CAS 769-42-6], 5,5-dimethylbarbituric acid [CAS 24448-94-0], 1,3-diethyl-barbituric acid [CAS 32479-73-5], 1,3,5-trimethylbarbituric acid [CAS 7358-61-4], 1,5,5-trimethylbarbituric acid [CAS 702-47-6], and tetramethylbarbituric acid [CAS 13566-66-0] in the temperature interval from T = 268 K to their respective melting temperatures. Temperatures, enthalpies and entropies of fusion, and the heat capacities of the solid compounds as a function of temperature are reported.
• Krasnov; Slesarev, Russian Journal of Organic Chemistry, 1997, vol. 33, # 4, p. 543 - 548
  作者：Krasnov、Slesarev

  DOI：——

  日期：——
• Krasnov, K. A.; Slesarev, V. I.; Artem'eva, Z. L., Journal of Organic Chemistry USSR (English Translation), 1989, vol. 25, # 7.2, p. 1402 - 1405
  作者：Krasnov, K. A.、Slesarev, V. I.、Artem'eva, Z. L.

  DOI：——

  日期：——