3-Benzyloxy-tetrahydrothiophen-1,1-dioxyd | 22179-13-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-Benzyloxy-tetrahydrothiophen-1,1-dioxyd
• 英文别名: 3-benzyloxy-tetrahydro-thiophene 1,1-dioxide；3-Benzyloxy-tetrahydro-thiophen-1,1-dioxid；3-(Benzyloxy)tetrahydrothiophene 1,1-dioxide；3-phenylmethoxythiolane 1,1-dioxide
• CAS: 22179-13-1
• 化学式: C₁₁H₁₄O₃S
• 分子量: 226.296
• InChiKey: CREJFXNRESKQFT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  51.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  Thieno[3,4-d]-1,3-dioxole, tetrahydro-2,2-dimethyl-,5,5-dioxide 、 氯化苄 以65%的产率得到
  参考文献：
  名称：

  TOLSTIKOV, G. A.;NOVITSKAYA, N. N.;SHULTS, EH. EH., ZH. ORGAN. XIMII, 1982, 18, N 6, 1301-1306

  摘要：

  DOI：

文献信息

• Addition products of 3.4-dehydrocyclotetramethylene sulphone
  申请人：GEN ANILINE &

  公开号：US02291798A1

  公开（公告）日：1942-08-04
• Tolstikov, G. A.; Novitskaya, N. N.; Shul'ts, E. E., Journal of Organic Chemistry USSR (English Translation), 1982, vol. 18, # 6, p. 1129 - 1134
  作者：Tolstikov, G. A.、Novitskaya, N. N.、Shul'ts, E. E.

  DOI：——

  日期：——
• INHIBITORS OF ERK NUCLEAR TRANSLOCATION
  申请人：Yeda Research and Development Co. Ltd.

  公开号：US20210292338A1

  公开（公告）日：2021-09-23

  Described herein are compounds having Formula I or Formula II: wherein each dashed line independently represents a saturated or unsaturated bond; R 1 and R′ 1 are aryl or heteroaryl as defined herein; and R 2 and R′ 2 are as defined herein. Further described is a method of inhibiting nuclear translocation of ERK1/2 in a cell, by contacting the cell with a compound having Formula I or Formula II. The compounds may also be for use in treating a disease or disorder associated with nuclear translocation of ERK1/2.
• [EN] INHIBITORS OF ERK NUCLEAR TRANSLOCATION<br/>[FR] INHIBITEURS DE LA TRANSLOCATION NUCLÉAIRE D'ERK
  申请人：YEDA RES & DEV

  公开号：WO2020115744A1

  公开（公告）日：2020-06-11

  Described herein are compounds having Formula (I) or Formula (II): wherein each dashed line independently represents a saturated or unsaturated bond; R1 and R'1 are aryl or heteroaryl as defined herein; and R 2 and R' 2 are as defined herein. Further described is a method of inhibiting nuclear translocation of ERK1/2 in a cell, by contacting the cell with a compound having Formula (I) or Formula (II). The compounds may also be for use in treating a disease or disorder associated with nuclear translocation of ERK1/2.
• TOLSTIKOV, G. A.;NOVITSKAYA, N. N.;SHULTS, EH. EH., ZH. ORGAN. XIMII, 1982, 18, N 6, 1301-1306
  作者：TOLSTIKOV, G. A.、NOVITSKAYA, N. N.、SHULTS, EH. EH.

  DOI：——

  日期：——